耐火陶瓷纤维流行病学和毒理学研究进展  

Research Advance in Toxicology and Epidemiology of Refractory Ceramic Fibers

作　　者：张敏[1] 张幸[1] 

机构地区：[1]浙江省医学科学院卫生学研究所,浙江杭州310013

出　　处：《环境与职业医学》2013年第1期63-66,共4页Journal of Environmental and Occupational Medicine

基　　金：浙江省科技厅重大与高发疾病防治专项(编号:2008C13029-2);浙江省卫生厅支撑学科建设基金(编号:11-ZC02);浙江省自然基金资助项目(编号:Y2090518)

摘　　要：石棉的主要替代品——耐火陶瓷纤维(refractory ceramic fibers,RCF),常被用作高温绝缘材料,在其生产或使用过程中,一些RCF是可吸入的,然而在欧洲和美国职业接触人群的流行病学研究中未证明其可致肺部疾病的发生。RCF比闪石石棉生物耐受性短,但比其他人造矿物纤维(man-made mineral fibers,MMMF)生物耐受性长。因此,使用不同毒理学方法研究的结果均表明,RCF可导致肺纤维化、肺癌和间皮瘤。本文综述报道RCF的流行病学研究和毒理学研究的进展,并对相关研究的前景加以展望。Refractory ceramic fibers （RCF） a substitute for asbestos, are often used as high-temperature insulation applications, but can be inhaled during production and using. However, epidemiological studies in Europe and the United States have not shown that occupational RCF exposure has association with the occurance of lung diseases. The tolerance of RCF is less than amphibole asbestos, but more than other man-made mineral fibers （MMMF）. Toxicology studies with various exposure methods have shown that RCF can cause pulmonary fibrosis, lung cancer, and mesothelioma. This article provided a comprehenS!ve and integrated review of the epidemiology toxicology of RCF, and illustrated perspectives for the further research.

关 键 词：耐火陶瓷纤维 流行病学 毒理学 

分 类 号：R135.2[医药卫生—劳动卫生]