杂多酸季铵盐双活性中心抗菌剂的合成及抑菌性能研究  

Synthesis and Antibacterial Property of Heteropoly Acid Quaternary Ammonium Salt Antimicrobial Agent with Double Active Center

作　　者：杨万丽[1,2] 王丽艳[2] 王清文[1] 

机构地区：[1]东北林业大学生物质材料科学与技术教育部重点实验室,哈尔滨150040 [2]齐齐哈尔大学化学与化学工程学院,齐齐哈尔161006

出　　处：《无机化学学报》2013年第2期295-302,共8页Chinese Journal of Inorganic Chemistry

基　　金：生物质材料科学与技术教育部重点实验室(东北林业大学)开放基金(No.2012-01);黑龙江省自然科学基金(No.B201116)资助项目

摘　　要：本文采取立体选择法合成以过渡元素V、Fe、Co和Ni为取代原子的Keggin结构的取代型磷钼杂多酸盐．在水热条件下与十二烷基三甲基溴化铵进行化合，得到了4种新的基于Keggin型多酸阴离子和季铵阳离子的复合物。通过红外（FT—IR）、紫外（UV—Visible）、热重（TG）、X射线衍射（XRD）、扫描电镜（SEM）、透射电镜（TEM）等手段进行了结构表征，并采用抑菌圈法对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌进行了抑菌活性研究。结果表明，所合成的复合物的分解温度较季铵盐提高了200℃：复合物的抑菌效果是季铵盐的2～3倍。Phosphomolybdic heteropolyacid salt with Keggin structure with transition elements V, Fe, Co and Ni as substituted atom were synthesized by the stereoselective synthesis method. Four new Keggin type complexes with polyoxoanions and quaternary ammonium cation were obtained from phosphormolybdic heteropolyacid salt and dodecyltrimethylammonium bromide under hydrothermal condition. The structures of all the polyoxoanions and organic composite were characterized by the infrared （FT-IR） spectra, the ultraviolet visible （UV-Visible） spectra, thermogravimetry （TG）, X-ray diffraction （XRD）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）. The antibacterial activities of composite were tested for staphylococcus aureus, bacillus subtilis and escherichia coli by the inhibition zone method. The results indicated that the complexes have higher decomposition temperature than quaternary ammonium salt with 200℃ increment. The antibacterial activities of complexes is 2-3 times of quaternary ammonium salt.

关 键 词：杂多酸 季铵盐 双活性中心 抑菌性能 

分 类 号：O614.511[理学—无机化学] O614.811[理学—化学]