山东沿海居民糖尿病及糖尿病前期患病率5年变迁研究  

Change in prevalence of diabetes mellitus and prediabetes during 5 years in Shandong coastal area

作　　者：赵世华[1] 王颜刚[1] 王萍[1] 李长贵[1] 孟冬梅[1] 王芳[1] 苗志敏[1] 陈颖[1] 王忠超[1] 韩琳[1] 刘艺[1] 阎胜利[1] 

机构地区：[1]青岛大学医学院附属医院内分泌科,山东省痛风病临床医学中心,山东省代谢性疾病重点实验室,266003

出　　处：《中华内分泌代谢杂志》2013年第1期9-13,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：科技部973计划前期研究专项（2010CB534900）

摘　　要：目的调查山东沿海地区20岁以上居民5年随访2型糖尿病及糖调节受损（IGR）患病情况及其影响因素。方法采用随机、分层、整群抽样的方法，入户调查青岛、烟台、威海、日照、东营常住居民5191名。结果（1）按照同一人口标化后，2009年糖尿病的标化患病率为9．51％，比2004年增加1．53％（P〈0．05）；其中男性标化患病率为9．86％、女性为9．26％，分别比2004年增加2．11％、0．94％（P〈0．05）。新诊断糖尿病374例，占所调查糖尿病患者的61．51％，较2004年高10．2％（P〈0．05）。（2）IGR标化患病率为11．86％，较2004年增加2．02％（P〈0．05）；其中男性标化患病率为14．19％，女性标化患病率为9．79％。（3）糖尿病和IGR患病率随年龄增长而升高，50岁以前男性、女性各年龄段糖尿病患病率较2004年均明显升高（P〈0．05）；60岁以前男、女各年龄段IGR患病率较2004年也明显升高（P〈0．05）。（4）IGR及糖尿病患者的舒张压、甘油三酯（TG）、总胆固醇（Tc）、低密度脂蛋白胆固醇（LDL—C）、血尿酸水平较2004年明显升高（P〈0．05）。糖尿病患者的TG水平高于IGR患者（P〈0．05），而血尿酸水平明显较低（P〈0．01）。（5）logistic回归分析显示年龄、体重指数、收缩压、TG、LDL—C为血糖调节异常的危险因素，高密度脂蛋白胆固醇、每日进食海产品量为糖调节异常的保护因素。结论5年间人群整体糖尿病和糖尿病前期患病率均有所增高，且呈明显年轻化，男性增加尤为显著；增龄、肥胖、高血压、脂代谢紊乱为糖尿病的危险因素，适量的海鲜摄入有助于血糖的控制；血尿酸在糖尿病启动阶段发挥重要作用。Objective To determine the changes in prevalence of type 2 diabetes mellitus （DM） and prediabetes in residents aged over 20 years in Shandong coastal areas during 2004-2009 years. Methods A random stratified cluster sampling was conducted, and 5191 inhabitants were investigated in Qingdao, Yantai, Weihai, Rizhao, and Dongying. Results （ 1 ） According to the uniform population standardization, the standardized rate of DM prevalence was 9.51% in 2009, increased by 1.53% （ P〈0.05 ） as compared with 2004. The standardized rates were 9.86% in males and 9.26% in females, increased by 2.11% and 0.94 % （ P〈0.05 ） respectively compared with 2004. In this epidemiological study, there were 374 newly diagnosed DM patients, accounting for 61.51% of the DM patients, increased by 10.2% （ P〈0.05 ） as compared with 2004. （ 2 ） the standardized rate of prediabetes was 11.86% in 2009, increased by 2.02% （P〈0.05） compared with 2004. The standardized rate was 14.19% in males and 9.79% in females. （ 3 ） The prevalence of DM in individuals aged under 50 years in 2009 was significantly higher than that in 2004 （ P〈0.05 ）. The prevalence of prediabetes in individuals aged under 60 years was also significantly higher than that in 2004 （P 〈 0. 05 ）. （4） Compared with 2004, the levels of diastolic blood pressure, serum triglyceride （TG）, total cholesterol （TC）, low density lipoprotein-cholesterol （LDL-C）, and uric acid in subjects with prediabetes and DM increased obviously in 2009 （ P〈0.05 ）. TG level in DM patients was higher than that in prediabetic patients （ P〈0.01 ）, while the serum uric acid level was lower （ P〈0.01 ）. （ 5 ） Logistic regression analysis showed that age, body mass index, systolic blood pressure regulation, while high density lipoprotein-cholesterol and TG, LDL-C were the risk factors for abnormal glucose daily intake of sea-food were the protective factors.Conclusion The prevalence of DM and prediabetes increased during 5 years �

关 键 词：糖尿病 糖尿病前期 患病率 山东沿海地区 

分 类 号：R587.1[医药卫生—内分泌]