无糖尿病史人群空腹血糖与冠心病发生及其严重程度的关系  

Association of fasting plasma glucose with the prevalence and severity of angiographic coronary artery disease in population with no history of diabetes

作　　者：桂明辉[1] 李湘[1] 陆志强[1] 高鑫[1] 

机构地区：[1]复旦大学附属中山医院内分泌科,上海200032

出　　处：《中华内分泌代谢杂志》2013年第1期29-32,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：复旦大学青年科学基金资助项目（09FQ61,EYF152040）;代谢病转化医学研究中心项目（985Ⅲ-YFX0302）;卫生部部属医院2011年国家临床重点专科建设项目[卫办医政函（2011）873号]

摘　　要：906例因高度疑诊冠心病行选择性冠状动脉造影并且既往无糖尿病病史的患者纳入本研究。根据空腹血糖（FPG）水平，将研究人群分为≤5．5mmol／L、5．6～6．0mmol／L、6．1～6．9mmol／L和≥7．0mmol／L组。主要冠状动脉或其主要分支直径有≥50％的狭窄即诊断为冠心病，冠状动脉病变严重程度以Gensini评分表示。对各组人群进行一般临床资料、生化指标、冠状动脉造影资料的比较，并分析与冠心病发生以及冠状动脉病变严重程度相关的危险因素。结果显示．4组间随着FPG水平升高冠心病发生比例逐渐增高，冠状动脉病变支数逐渐增多，Gensini评分逐渐增加，差异有统计学意义（P〈0．05或P〈0．01）。FPG与冠心病发生（P=0．004）和Gensini评分明显相关（P=0．010），提示FPG是冠心病发生以及冠状动脉病变加重的独立危险因素。A total of 906 subjects with no history of diabetes who had undergone coronary angiography were included in this study and categorized into four groups according to the level of fasting plasma glucose （FPG） ： ≤5.5 mmol/L, 5.6-6.0 mmol/L, 6.1-6.9 mmol/L, and ≥7.0 mmol/L. Significant coronary artery disease （CAD） was defined as ≥ 50% reduction of lumen diameter at least in one major coronary artery. The severity of coronary atherosclerosis was defined by the Gensini score. The clinical data, laboratory indexes, and coronary angiography results were compared among various groups. The risk factors for the prevalence and severity of angiographic CAD were analyzed. The results showed that the prevalence of angiographic CAD, the number of diseased vessels, and the Gensini score were increasing with increasing FPG levels among four groups （ P〈0. 05 or P〈0.01 ）. The FPG level was significantly correlated with angiographic CAD （ P = 0. 004 ） and the Gensini score （ P = 0.010 ）, suggesting that FPG was an independent risk factor for the prevalence and severity of angiographic CAD.

关 键 词：空腹血糖 冠心病 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]