老年男性骨质疏松患者血清脂联素与骨密度及骨转换生化指标的关系  

Relationship among serum adiponectin,bone mineral density,and bone turnover biochemical markers in senile male osteoporosis patients

作　　者：柴瑛[1] 鲍婧[1] 乔建民[1] 周成福[1] 柴国禄[1] 

机构地区：[1]佳木斯大学附属第一院骨科,佳木斯154003

出　　处：《中国骨质疏松杂志》2013年第1期14-16,共3页Chinese Journal of Osteoporosis

基　　金：佳木斯大学科学技术面上项目(S2011-016)

摘　　要：目的探讨老年男性骨质疏松患者血清脂联素(Adiponectin,APN)水平的变化及其与骨密度(BMD)及骨转换生化指标的关系。方法采用酶联免疫法(ELISA)测定89例老年男性骨质疏松患者和50例正常男性老年人血清APN、骨碱性磷酸酶(BAP)、骨钙素(BGP)、I型胶原氨基末端肽(NTX),采用美国NORLAND Excell-plus双能X线骨密度测定仪分别测定其正位腰椎(L2-4)及左侧股骨颈处BMD。结果老年男性骨质疏松患者正位腰椎及左侧股骨颈BMD、血清APN、BAP、BGP水平较正常男性老年人明显降低(均P<0.01),血清NTX水平较正常男性老年人明显升高(P<0.01)。老年男性骨质疏松患者血清APN水平与患者正位腰椎及左侧股骨颈BMD、血清BAP、BGP水平呈明显正相关(r=0.468,r=0.487,r=0.402,r=0.415,均P<0.01),与患者血清NTX水平呈明显负相关(r=-0.498,P<0.01)。结论血清脂联素水平降低在老年男性骨质疏松的发病中可能发挥重要作用。Objective To investigate the changes of serum adiponectin （APN） and the relationship among serum APN, bone mineral density （BMD） , and bone turnover biochemical markers in senile male patients with osteoporosis. Methods A total of 89 senile male patients with osteoporosis and 50 healthy senile males were enrolled. The serum APN, bone alkaline phosphatase （BAP） , bone gla protein （BGP） , and cross- linked N-telopeptides of type Ⅰ collagen （NTX） were measured using ELISA. BMD of the lumbar vertebrae 2-4 and the left femoral neck was measured using Excell-plus dual energy X-ray absorptiometry （NORLAND, USA）. Results BMD of L2-4 and the left femoral neck, serum APN, BAP, and BGP in senile male patients with osteoporosis were significantly lower than those in healthy senile males （P 〈 0. 01 ）, but serum NTX was significantly higher than that in healthy senile males （ P 〈 0.01 ）. Serum APN was positively correlated with BMD of L2-4 and the left femoral neck, serum BAP, and BGP in senile patients with osteoporosis （r = 0. 468, r = 0. 487, r = 0. 402, r = 0. 415, P 〈 0. 01 ）, but negatively correlated with serum NTX （r = - 0. 498, P 〈 0.01 ）. Conclusion The decrease of serum APN may play an important role in the pathogenesis of osteoporosis in senile male patients.

关 键 词：骨质疏松 脂联素 骨碱性磷酸酶 骨钙素 Ⅰ型胶原氨基末端肽 

分 类 号：R587.1[医药卫生—内分泌]