血浆脂蛋白相关性磷脂酶A2活性与颈动脉内中膜厚度的关系  

Relationship of lipoprotein-associated phospholipase A2 activity with carotid intima-media thickness

作　　者：曾繁芳[1] 蔡安平[2,3] 刘幼文[1] 金光临[1] 王涓[1] 潘楚梅[1] 

机构地区：[1]深圳市孙逸仙心血管医院心内科,广东深圳518020 [2]广东省心血管病研究所心内科 [3]广东省人民医院广东省医学科学院,广州510000

出　　处：《岭南心血管病杂志》2013年第1期77-79,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨血浆脂蛋白相关性磷脂酶A2(lipoprotein-associated phosphalipase A2,Lp-PLA2)活性与颈动脉内中膜厚度(carotid intima-media thickness,CIMT)关系。方法收集168例患者,依据CIMT将患者分为A组(CIMT>0.9 mm)和B组(CIMT<0.9 mm),检测两组血浆Lp-PLA2活性及其他指标,并分析Lp-PLA2活性及其他指标与CIMT的关系。结果 (1)与B组相比,A组血浆Lp-PLA2活性明显升高,而血浆高密度脂蛋白胆固醇浓度则低于B组,差异有统计学意义(P<0.05);(2)Pearson或Spearman相关分析结果提示吸烟和Lp-PLA2活性与CIMT厚度呈正相关(r=0.665,P=0.168;r=0.815,P=0.001),而高密度脂蛋白胆固醇则与CIMT呈负相关(r=-0.754,P=0.002)。结论对于仅合并吸烟及血浆低高密度脂蛋白胆固醇浓度的患者,其血浆Lp-PLA2活性升高与CIMT呈正相关。Objectives To investigate the relationship of lipoprotein-associated phospholipase A2 （Lp-PLA2） activity with carotid intima-media thickness （CIMT）. Methods Totally 168 patients were enrolled and assigned into two groups according to the values of CIMT （group A, CIMT 〉 0.9 mm; group B, CIMT 〈 0.9 mm）. Activity of Lp-PLA2 and values of other variables were evaluated. Relationships of Lp-PLA2 activity and other variables with CIMT were analyzed. Results （ 1 ） Compared to group B, activity of Lp-PLA2 was significantly higher and serum level of high- density lipoprotein cholesterol （HDL-C） was significantly lower in group A （P〈0.05）; （2） Pearson or Spearman correlation analysis indicated that smoking and activity of Lp-PLA2 were positively correlated with CIMT （r=0.665, P= 0.168;r=0.815,P=0.001）, while serum level of HDL-C was negatively correlated with CIMT （r=-0.754,P=0.002）. Conclusions Enhanced activity of Lp-PLA2 in patients barely with smoking and low serum level of HDL-C was positively correlated with CIMT.

关 键 词：颈动脉内中膜厚度 脂蛋白相关性磷脂酶A2 相关分析 

分 类 号：R543.2[医药卫生—心血管疾病]