氯诺昔康注射液椎管内给药对家兔脊髓的影响  

Effect of Lomoxicam injection by lumbar administration on spinal cord in rabbits

作　　者：胡玲[1] 易先慧 

机构地区：[1]武汉科技大学附属天佑医院,湖北武汉430060 [2]湖北省宜昌市三峡仁和医院,湖北宜昌443000

出　　处：《现代中西医结合杂志》2013年第5期474-476,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨氯诺昔康椎管内给药对家兔的镇痛效果及不良反应。方法选择健康成年大白兔24只,随机分成A组、B组和C组各8只,A组和B组均行硬膜外置管。A组从硬膜外腔缓慢给生理盐水2 mL,B组给氯诺昔康0.75 mg/kg(共2 mL),C组静脉给氯诺昔康0.75 mg/kg(共2 mL)。给药5 min和术后12 min分别观察家兔对热敏度的耐受情况并记录耐受时间t1和t2。实验完毕后处死兔子取出脊髓标本并观察受损情况。结果与A组比较,B组和C组耐受时间延长(P均<0.05);C组与B组耐受时间比较亦有显著性差异(P<0.05);C组t2较t1延长,有显著性差异(P<0.05);A、C 2组兔脊髓切片内未见损害性改变,B组绝大部分切片均可见神经元细胞变性等损害性改变。结论氯诺昔康对痛觉过敏状态有良好的镇痛效应,但椎管内给药后对脊髓有一定的损害作用,故不适合硬膜外腔给药。Objective It is to explore the analgesic effect and side effect of Lomoxicam by epidural administration in rabbit models. Methods Twenty four healthy adult rabbits were randomly divided into three groups： groupA, group B and group C. Both group A and group B received epidural catheterization. Group A was given normal saline 2 mL slowly and groupB was giv- en Lomoxicam O. 75 mg/kg（2 mL in total） both from epidural cavity. Group C was given Lomoxicam O. 75 mg/kg（2 mL in to- tal） by intravenous injection. In 5 minute,12 hours after Lidocaine administration the degree of resistance to thermal condi- tions was observed and resistance time tt and t2 were recorded. At the end of the experiment the animals were killed to get spi- nal cord to observe its injury degree. Results Compared with that in group A, the resistance time in group B and group C in- creased obviously, the differences were significant（P 〈 0. 05）. There was significant difference in the time between group B and group C （ P 〈 O. 05 ）. t2 was longer than t~ in group C, and the difference was significant （ P 〈 0.05 ）. No damage change was found in spinal specimen in both group A and group C, but the danmge changes such as neurodegeneration were found in most section in group B. Conclusion Lomoxicam has a good analgesic effect on hyperalgesia state,but the epidural injeetion of lomoxicam shows certain harmful effect on spinal cord, so it is unsuited for lumbar administration.

关 键 词：氯诺昔康 椎管内给药 脊髓 

分 类 号：R332[医药卫生—人体生理学]