邵阳市某医院2007—2011年ICU患者感染病原菌分布及耐药性分析  

Pathogenic Bacterium Distribution and Drug Resistance Analysis of Infected Patients in Intensive Care Unit of Shaoyang City Hospital during 2007—2011

作　　者：王琴 罗甫花[3] 王朝燕[3] 

机构地区：[1]邵阳市宝庆精神病医院 [2]邵阳市老年病医院检验科,湖南邵阳422000 [3]邵阳市第一人民医院检验科,湖南邵阳422000

出　　处：《临床误诊误治》2013年第1期87-90,共4页Clinical Misdiagnosis & Mistherapy

摘　　要：目的了解重症监护病房(ICU)患者感染病原菌的分布特点及耐药性,为临床合理使用抗菌药物提供科学依据。方法对2007年1月—2011年12月邵阳市第一人民医院ICU住院患者各类感染性标本分离的1080株病原菌资料进行回顾性分析。结果本组1080株菌株中革兰阴性菌702株(65%),革兰阳性菌355株(32.87%),真菌23株(2.13%)。前5位病原菌依次为铜绿假单胞菌(235株)、金黄色葡萄球菌(191株)、大肠埃希菌(163株)、肺炎克雷伯菌(155株)和鲍曼不动杆菌(78株)。革兰阳性菌均对万古霉素、利奈唑胺和替考拉宁敏感,对其他抗生素表现出不同程度的耐药,其中耐甲氧西林金黄色葡萄球菌(MRSA)检出率为67%(126/191)。革兰阴性菌对多种抗菌药物的耐药率>70%,显示多药耐药较严重。结论该院ICU患者以革兰阴性杆菌感染为主,多种感染菌呈现多重性耐药,临床应采取有效措施以减少多重耐药菌的产生,有效预防和控制多重耐药菌的传播。Objective To investigate the characteristics of pathogenic bacterium distribution and drug resistance of infected patients in intensive care unit （ICU） in order to provide scientific references for rational use of antibiotics. Methods Clinical data of 1080 strains isolated from pathogenic bacteria in 1CU patients in First People~ Hospital of Shaoyang City during January 2007 and December 2011 were retrospectively analyzed. Results Among the isolated 1080 pathogenic strains, there were 702 strains （65%） of gram-negative bacteria, 355 strains （32.87%） of gram-positlve bacteria, 23 strains （2.13%） of fungi and 39 strains of others. The top five pathogenic bacteria were 235 strains of pseudomonas aeruginosa, 191 strains of staphylococcus aureus, 163 strains of escherichia coli, 155 strains of klebsiella pneumoniae and 78 strains of acinetobacter baumannii. Gram-positive bacteria was sensi- tive to Vancomycin, linezolid and teicoplanin, and had certain resistance to other antibiotics and the detection rate was 67% （126/ 191 ） of Methicillin resistant S. aureus （MRSA）. The resistance rate of dram-negative bacteria to various antibacterials was over 70% indicating strong muhidrug resistance. Conclusion The gram negative bacilli is the main infected pathogens in ICU patients of this hospital. Many kinds of bacteria show multiple resistance. Comprehensive measures should be taken to reduce the incidence rate of muhi-drug resistance organism （MDRO） and to effectively prevent and control the transmission of MDRO.

关 键 词：重症监护病房 病原菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]