银屑病并发砷中毒  

Psoriasis complicated by an arsenic poisoning

作　　者：栾莉[1] 张振颖[1] 刘晓明[1] 

机构地区：[1]大连医科大学附属第一医院皮肤科,辽宁大连116011

出　　处：《临床皮肤科杂志》2013年第2期95-97,共3页Journal of Clinical Dermatology

摘　　要：报告1例银屑病并发砷中毒。患者女,24岁。躯干、四肢、面颈部渐进性变黑,双手掌、足底角质渐进性增厚1年。皮肤科检查:躯干、四肢、面颈部弥漫性的灰黑色色素沉着,躯干部在色素沉着基础上可见米粒大点状的色素脱失斑,周边有细小的鳞屑,手掌和足底均可见黄色角化性丘疹,融合成片。实验室检查:肝功能受损,尿砷升高,结合患者临床表现、实验室检查结果和二巯基丙磺钠驱砷治疗有效,银屑病并发砷中毒诊断明确。A case of psoriasis with arsenic poisoning is reported. The clinical manifestations included hyperpigmentation on the trunk, limbs, face and neck, and hyperkeratosis on palms and soles. The laboratory tests showed abnormal hepatic function and a high level of urine arsenate. Based on the clinical manifestations, laboratory tests and the effective treatment responses to sodium dimercaptopropane sulfonate, the patient was diagnosed as psoriasis accompanied with arsenic poisoning. The present case and literature review demonstrate that arsenate has beneficial effects by suppressing keratinocyte proliferation and inducing apoptosis. At same time arsenate could cause accumulation poisoning. In order to maximize the therapeutic efficacy and mini- mize the side effects, more basic and clinical studies should be conducted to determine the best dose of arsenate. In addition to closely monitoring the administration of arsenate containing medication, a standard for its clinical usage should be established.

关 键 词：银屑病 砷中毒 治疗 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R155.33[医药卫生—临床医学]