百瑞口服液澄清工艺研究  

Study on clarification process of Bairui oral liquid

作　　者：闫俊 宣伟东 卞俊 

机构地区：[1]解放军411医院药学科,上海200434 [2]江西中医学院药学院,江西南昌333004

出　　处：《药学实践杂志》2013年第1期32-34,共3页Journal of Pharmaceutical Practice

基　　金：上海市卫生局局级科研课题(2012085号)

摘　　要：目的采用Ⅱ型ZTC1+1天然澄清剂,建立百瑞口服液的澄清工艺。方法考察澄清剂的加入顺序、加入量、澄清时间对口服液澄明度的影响;采用HPLC法测定口服液中紫云英苷含量,采用紫外分光光度法测定口服液中总黄酮含量。结果确定了口服液的澄清工艺:以先B组分后A组分的次序加入20%的澄清剂,各组分的澄清时间均为12 h。结论 ZTC1+1天然澄清剂不影响紫云英苷及总黄酮等有效成分的含量,可作为制备百瑞口服液的除杂澄清工艺。Objective To establish a optimum clarification process of Bairui oral liquid with new ZTCI ＋ 1-Ⅱ natural clarif- ying agents. Methods The effects on clarification of Bairui oral liquid were evaluated based on the factors such as adding sequence, added amount and clarification time of ZTC1 ＋ 1-Ⅱ clarifiers A and B. The contents of astragalin and total flavones were determinate by the HPLC and UV methods respectively to evaluate the removing activities of ZTC1 ＋ 1 - Ⅱ on active components. Results The selected clarification process conditions were ： adding 20% percentage of each components of ZTCI ＋ 1 -Ⅱ to the condensed herb extract solutiml, the adding sequence was clarifiers B before clarifiers A, and the elarifieation time was 12 b, respectively. Conclusion The contents of astragalin and total flavones were not decreased by clarification pr0cess, ZTC1 ＋ 1- Ⅱ could be used as the removing impurity of Bairui oral liquid.

关 键 词：百蕊草 口服液 ZTC1+1-Ⅱ 澄清工艺 

分 类 号：R94[医药卫生—药剂学]