肝癌切除术后口服UDCA血清胆汁酸浓度变化情况分析  

Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection

作　　者：金柔男[1] 李乐乐[2] 龚纯贵[1] 

机构地区：[1]第二军医大学东方肝胆外科医院药材科,上海200438 [2]第二军医大学,药学本科2006级上海200433

出　　处：《药学实践杂志》2013年第1期45-48,共4页Journal of Pharmaceutical Practice

摘　　要：目的对原发性肝癌手术切除患者服用熊去氧胆酸(ursodeoxycholic acid,UDCA)后血清胆汁酸浓度变化进行分析,为临床治疗提供合理建议。方法抽取2009年1月～2010年1月服用过熊去氧胆酸的原发性肝癌手术患者病历89份进行分析。结果①用药前血清胆汁酸浓度变化值最大值为131.10μmol/L,最小值为-69.00μmol/L,四分位数间距为15.30μmol/L;用药后血清胆汁酸变化值最大为275.20μmol/L,最小值为-49.00μmol/L,四分位数间距为30.50μmol/L。②与用药前血清胆汁酸浓度变化相比,用药后血清胆汁酸浓度明显升高,P<0.01。③这种升高与用药前的Child-Pugh评分显著相关,P<0.01,与熊去氧胆酸用药剂量、术中出血量、肝门阻断时间、手术者、肝硬化程度等因素不相关。结论原发性肝癌手术患者服用熊去氧胆酸应考虑的首要因素是用药前的Child-Pugh评分。Objective To analyze the serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection and provide reasonable recommendations for clinical staffs. Methods 89 cases with hepatocellular carcinoma after taking UDCA had been analyzed during 2009.01 to 2010.01. Results Serum bile acid concentration changes before medica- tion of UDCA had been showed that the maximum value was 131. 10 ixmol/L, the minimum value was - 69.00 txmol/L, quartile spacing was 15.30 p^mol/L, and after medication, the maximum value was 275. 20 ixmol/L, the minimum value was -49. 00 ~mol/L, quartile spacing 30.50 Ixmol/L. The serum bile acid concentrations after medication of UDCA had increased significantly compared with the status before medication, P 〈 0.01. The Child-Pugh scores before the medication of UDCA was correlated to the changes of serum bile acid after the medication of UDCA,P 〈 0.01. The other variables, UDCA dosage, the amount of bleeding dur- ing operation , blocking time of portal vein, the different surgeon, cirrhosis were not correlated to the changes of serum bile acid after the medication of UDCA. Conclusion The Child-Pugh scores before the medication of UDCA should be the prime considerable fac- tor as concerned.

关 键 词：熊去氧胆酸 肝功能 血清胆汁酸 

分 类 号：R975[医药卫生—药品]