慢性阻塞性肺疾病中医痰证素与气道炎症的相关性研究  

Correlation research between TCM phlegm syndrome element and airway inflammation in patients with chronic obstructive pulmonary disease

作　　者：刘燕鸿[1] 洪敏俐[2] 黄小华[2] 刘朝辉[2] 郑伟彬[2] 洪春霖[2] 高凌云[2] 陈文喜[2] 李灿东[3] 

机构地区：[1]福建中医药大学,福州350108 [2]福建中医药大学附属漳州市中医院,漳州363000 [3]福建中医药大学中医证研究基地,福州350108

出　　处：《中华中医药杂志》2013年第2期507-510,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：福建省卫生厅青年科研课题(No.2010-1-47);陈可冀中西医结合发展基金(No.CKJ2010004);福建省自然基金课题(No.2011J01391);漳州市科技局课题(No.Z20111064);福建省教育厅课题(No.JB10085)~~

摘　　要：目的:探讨慢性阻塞性肺疾病(COPD)稳定期中医痰证素与气道炎症的相关性。方法:选择103例COPD稳定期患者为研究对象,采用证素辨证和积分的方法,提取COPD病性证素痰,探讨证素痰的严重度与诱导痰白细胞总数及其分类的相关性。结果:病性证素痰的严重度根据痰证素积分由低至高分为3级,痰证素积分、诱导痰中性粒细胞百分比及巨噬细胞百分比各组间比较差异均有统计学意义(P<0.01),且痰证素积分与诱导痰中性粒细胞百分比呈高度正相关(r=0.992,P<0.01),与巨噬细胞百分比呈高度负相关(r=-0.779,P<0.01);诱导痰嗜酸性粒细胞百分比1、2级显著高于3级,差异有统计学意义(P<0.05),且痰证素积分与嗜酸性粒细胞百分比呈负相关(r=-0.309,P<0.01)。结论:中医证素痰是COPD稳定期患者重要的病理因素,且随着气道炎症程度增加而加重。Objective： To study the correlation between traditional Chinese medicine（TCM） phlegm syndrome element and airway inflammation in patients with stable chronic obstructive pulmonary disease（COPD）. Methods： A total of 103 patients with stable COPD were observed by syndrome elements differentiation and integral methods. The syndrome element phlegm of the disease nature was extracted. The correlation between the severity of phlegm syndrome element and total leukocyte counts and differential leukocyte counts in induced sputum was explored. Results： The severity of phlegm syndrome element was divided into three levels according to the phlegm syndrome element integral from low to high. The phlegm syndrome element integral, the percentage of neutrophils and macrophages in induced sputum were significant differences among three groups （P〈0.01）. Phlegm syndrome element integral high positively correlated with the percentage of neutrophils and negatively correlated with the percentage of macrophages in induced sputum（r=-0.992, r=--0.779, P〈0.01, respectively）. The percentage of eosinophils in sputum in the first and second levels were significant higher than those in the third level（P〈0.05）; Phlegm syndrome element integral negatively correlated with the percentage of eosinophils in induced sputum（r=-0.309, P〈0.01）. Conclusion： TCM syndrome element phlegm is the important pathologic factor, its severity would aggregate with the exacerbation of airway inflammation in patients with stable COPD.

关 键 词：慢性阻塞性肺疾病 痰证素 诱导痰细胞学 

分 类 号：R259[医药卫生—中西医结合]