清热化滞颗粒促胃肠动力作用机制研究  

Study of the mechanism of Qingre Huazhi Granule on the gastrointestinal motility

作　　者：赵霞[1] 汪受传[1] 

机构地区：[1]南京中医药大学附属医院,南京210029

出　　处：《中华中医药杂志》2013年第2期510-512,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨清热化滞颗粒对胃肠动力的影响。方法:测定实验大鼠胃蛋白酶的活性、胃酸含量;小鼠小肠推进率、小鼠血浆胃动素(MTL)、胃泌素(GAS)、生长抑素(SS)和血管活性肠肽(VIP)的水平。结果:清热化滞颗粒能提高大鼠胃蛋白酶活性并对盐酸阿托品负荷小鼠小肠推进功能具有促进作用,与空白对照组及药物对照组比较,差异有统计学意义(P<0.05,P<0.01);模型建成后,小鼠血浆SS的含量增加,MTL、GAS含量降低;灌喂清热化滞颗粒后SS降低,MTL、GAS增加,且与模型组比较有显著性差异(P<0.01)。结论:清热化滞颗粒治疗小儿积滞化热证的作用机制可能与其通过调节胃肠激素,促进胃肠蠕动,从而促进胃肠动力有关。Objective： To probe the effect of Qingre Huazhi Granule on the gastrointestinal motility. Methods： By determination of the activity of gastric protease and the volume of gastric acid in rat; the driving rate in the small intestine, MTL, GAS, SS and VIP in the blood plasma in the model mice. Results： Compared with the normal group and drug control group, Qingre Huazhi Granule increased the total amount of gastric acid and free acid; and raised the activity of gastric protease; promoted the driving rate of small intestine in the mice with loaded atropine hydrochloride（P〈0.05, P〈0.01）. The amount of MTL and GAS in the blood plasma decreased, and the amount of SS increased after the model was established, but the MTL and GAS increased and the SS decreased after using Qingre Huazhi Granule, there were significant differences（P〈0.01）. Conclusion： The mechanism of the Granule for retention of food transforming into heat syndrome in children is probably associated with its regulation of the gastrointestinal hormone and its promotion of the gastrointestinal movement.

关 键 词：清热化滞颗粒 积滞化热模型 胃肠激素 胃酸 胃蛋白酶 

分 类 号：R285[医药卫生—中药学]