黄芪注射液对不稳定型心绞痛患者高敏C反应蛋白等因子及左室功能的影响  

THE EFFECTION OF ASTRAGALUS INJECTION ON PLASMA HS-CRP、TNF-α、SFAS、VWF AND VENTRICULUS SINISTER FUNCTION IN PATIENTS WITH UNSTABLE ANGINA PECTORIS

作　　者：刘卫民[1] 林丽[1] 王国振[1] 王月[1] 单苏民[1] 

机构地区：[1]山东省阳信县人民医院,滨州医学院实践教学医院,251800

出　　处：《中国煤炭工业医学杂志》2013年第1期24-27,共4页Chinese Journal of Coal Industry Medicine

摘　　要：目的观察不同剂量的黄芪注射液对不稳定型心绞痛(UAP)患者的血浆高敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、可溶性细胞调亡因子Fas(sFas)、血管性血友病因子(vWF)以及左室功能的影响。方法将190例UAP患者按照数字表法分为A、B、C三组。所有患者均给予抑制血小板聚集、抗心绞痛等常规治疗。同时,B组患者加用黄芪注射液30～50ml,而C组患者加用60～80ml入液静脉滴注,1次/d,10d为一疗程,应用1～2个疗程。观察三组患者的临床疗效以及治疗前后血浆hs-CRP、TNF-α、sFas和vWF水平以及左室功能的变化。结果黄芪注射液可以明显改善UAP患者的左室功能,降低血浆hs-CRP、TNF-α、sFas和vWF水平,统计学比较差异有统计学意义(P<0.05或P<0.01),且以大剂量者为优。结论黄芪注射液治疗UAP疗效满意,能够改善左室功能,抑制炎症反应和细胞凋亡,且以大剂量为优。Objective To observe the effection of astragallus injection on plasma high- sensitive C- reactive protein （hs - CRP）, tumor necrosis factor alpha（TNF-α）, soluble cell apoptosis factor Fas（sFas） ,von Willebrand factor（vWF） and Ventriculus sinister function in patients with unstable angina pectoris（UAP）. Methods 190 patients with UAP who received the conventional therapies,such as antiplatelet and antianginal therapies were randomized into three groups of A, B and C, and 65 patients in the B group were given astragalus injecttion30- 50ml, while 72patients in the C group were given 60-80ml, iv drip, qd, for 10 to 20 days. Results Astragalus injection could evidently improve the Ventriculus sinister function of UAP,decrease levels of plasma hs- CRP,TNF-α,sFas and vWF. And it is effective in the high intensity group （P 〈0.05 or P〈0.01）. Conclosion The efficacy of astragalus injection on UAP is satisfactory,can improve the Ventrieulus sinister function. And it＇s mechanism related to the anti- inflammation response and cell apoptosis. It is effective in the high intensity group.

关 键 词：不稳定型心绞痛 黄芪注射液 高敏C反应蛋白 肿瘤坏死因子 可溶性细胞调亡因子Fas 血管性血友病因子 左室功能 

分 类 号：R972.3[医药卫生—药品]