N,O-羧甲基壳聚糖的制备及其结构表征  

Synthesis and characterization of N,O-carboxymethyl chitosan

作　　者：郑雪[1] 姜彤彤[1] 宋舒苹[1] 蒲俊文[1] 吕卫军[2] 

机构地区：[1]北京林业大学,北京100083 [2]中国制浆造纸研究院,北京100102

出　　处：《中华纸业》2013年第2期40-43,共4页China Pulp & Paper Industry

基　　金：北京市自然科学基金资助项目(2112032)

摘　　要：壳聚糖和氯乙酸反应,在低碱浓的条件下合成了水溶性较好的总取代度高、N位取代度低的N,O-羧甲基壳聚糖,并采用单因素实验优化了制备条件,结果表明:当反应温度为90℃,壳聚糖与氯乙酸质量比为1:4时,制备的N,O-羧甲基壳聚糖的取代度为1.567。用红外光谱(FTIR)和热重分析(TGA)对N,O-羧甲基壳聚糖进行了结构表征,发现N,O-羧甲基壳聚糖的N位和O位均引入了羧甲基,但改性后N,O-羧甲基壳聚糖的热稳定性比壳聚糖差,热分解温度比壳聚糖低。N, O-Carboxymethyl chitosan with better water-solubility, high total substitution degree and low N substitution degree was synthesized by modifying chitosan with chloroacetic acid under low alkali concentration. Single factor experiments were used to optimize the preparation conditions, and the results showed that the substitution degree of N, O-Carboxymethyl chitosan is 1.566 when the temperature is 90℃ and the mass ratio of chitosan to chloroacetic acid is 1:4. The structure of N,O-carboxymethyl chitosan was characterized by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). The results show that the substitution reaction occurred on both N element and O element, but the thermostability of N, O-carboxymethy chitosan is worse than chitosan and thermal decomposition temperature is lower than chitosan.

关 键 词：O-羧甲基壳聚糖 结构表征 制备 脱乙酰甲壳质 阳离子聚合物 D-葡萄糖 生物降解性 生物相容性 

分 类 号：TS727.2[轻工技术与工程—制浆造纸工程]