扩散张量成像在兔肾栓塞模型中的应用探讨  

The Analysis of MR diffusion tensor imaging in the rabbit model of kidney embolization

作　　者：王宝明[1,2] 杨海山[1] 

机构地区：[1]吉林大学中日联谊医院放射科,吉林长春130033 [2]中国医科大学附属第四医院介入科

出　　处：《中国实验诊断学》2013年第1期37-39,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨磁共振扩散张量成像(DTI)在兔肾栓塞模型中的应用。方法 20只新西兰试验兔,采用股动脉插管行肾动脉栓塞术,术后行肾脏DTI检查。分析肾脏皮质、髓质以的表观扩散系数(ADC)、分数各向异性(FA值)的变化,并行髓质纤维束成像。结果正常肾肾皮质ADC、FA于正常肾肾髓质比较,两者差异具有显著性(P<0.05),正常肾与栓塞肾30min内肾皮质ADC、FA比较,差异没有统计学意义,但正常肾与栓塞肾肾髓质ADC、FA值差异有统计学意义。结论 DTI可测定肾脏动脉栓塞病变中水分子运动的差异,并提供有关组织细微结构变化的信息,对肾脏动脉栓塞性病变的早期诊断有重要意义。Objective To evaluate the application of the diffusion tensor imaging（DTI） in the rabbit model of kidney embolization. Methods 20 rabbits were embolizated unilateral renal artery, and then all rabbits were examined with DTI using a 1.5T MR scanning within 30 minute. ADC,FA values in the cortex,medulla were calculated and analyzed followed by medullary fiber tractography. Results In normol kidney, there were significant differences （P〈0.05） in ADC,FA between cortex and medullary. In embolization kidney. There were no differences （P〉0.05） in ADC^FA be- tween cortex of normal kidney and cortex of embolizated kidney within 30 minute. There were significant differences （P 〈0.05） in ADC,FA between medullary of normal kidney and medullary of embolizated kidney within 30 minute. Con- clusion DTI can quantitatively determinate the molecular motion of water in normal kidney and the embolizated kid- ney,and provide information on subtle structural changes,which could be used for early diagnosis of kidney emolizated disease.

关 键 词：弥散 扩散张量成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]