对慢性闭胸犬评价潘生丁负荷心肌声学造影探测冠状动脉狭窄  

Dipyridamole Stress Myocardial Contrast Echocardiography in Detection Coronary Stenosis:A Chest-closed Dog Trial

作　　者：宾建平[1] Kevin Wei Robert A.Pelberg 刘伊丽 查道刚 陆洁 Sanjiv Kaul 

机构地区：[1]南方医院心内科,广州市510515 [2]美国弗吉尼亚大学医学中心心内科

出　　处：《中国超声医学杂志》2000年第6期409-412,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然基金资助!(编号39870329)

摘　　要：目的 :为评价潘生丁负荷心肌声学造影 ( MCE)诊断静息状态无血流限制的冠脉狭窄的准确性。方法 :以安放“水膨胀式”缩窄器 ( Ameroid)的方法建立慢性多支冠脉狭窄犬模型 ,术后 7天～ 10天同步进行经外周静脉注射微泡法 MCE和放射性微球测定心肌血流量 ( MBF)。结果 :静息状态未见明显灌注缺损。负荷状态时 ,异常冠脉供血区 ( MBF储备 <3)呈现灌注缺损 ,峰值声强度 ( VI)较正常冠脉供血区低 ( 33± 13与 5 0± 12 ;P<0 .0 1) ;且异常和正常冠脉供血区峰值 VI比值 ( 0 .6± 0 .2 )与相应 MBF比值呈良好的线性正相关 ( r=0 .89,P<0 .0 0 0 1)。结论 :潘生丁负荷Objective:To assess the accuracy of myocardial contrast echocardiography(MCE)in combination with dipyridamole stress in detecting nonflowlimited coronary stenoses at rest.Methods:MCE was performed by intravenous injection of microbubbles(MRX115)and radiolabled microspheres to measure myocardial blood flow(MBF)in 17 chest closed dogsChronical instrumental coronary stenoses models were created by placing ameroid contrictorsData were acquired in 710 postoperative days.Results:No perfusion defects were noted at baselineHowever,perfusion defects were seen in abnormal beds(MBF reserve<3)during dipyridamole stressThe peak video intensity(VI)in the abnormal beds was lower(33±13 ver 50±12; P<001)than in normal beds with dipyridamoleAn excellent linear relation was noted between the peak VI ratio(06±02,abnormal/normal)and that of MBF using dipyridamole(r=089,P<00001).Conclusion:MCF with dipyridamole may be clinically useful for the detection and quantification of coronary stenoses.

关 键 词：心肌声学造影 冠脉狭窄 潘生丁 心肌血流量 

分 类 号：R445.1[医药卫生—影像医学与核医学]