支气管哮喘发病相关因素的病例对照研究  

Case-control study on the correlative causes of bronchial asthma

作　　者：娄月妍[1] 郭胤仕[1] 

机构地区：[1]上海交通大学医学院附属仁济医院呼吸科,上海200127

出　　处：《临床肺科杂志》2013年第3期447-449,共3页Journal of Clinical Pulmonary Medicine

基　　金：卫生部行业科研专项项目(编号200802001)

摘　　要：目的探讨支气管哮喘发病的相关因素。方法使用成组的病例对照研究方法,采用问卷调查方式,对调查数据进行单因素和多因素非条件Logistic回归分析。结果单因素Logistic回归分析结果显示,有10个因素与支气管哮喘有关联;多因素Logistic回归分析显示,6个因素被选入,家庭人均拥有轿车量越多(OR为2.901)、最近10年至少染过一次头发(OR为2.620)、父母兄弟姐妹子女及父系或母系亲属患有过敏性疾病(OR为1.225)、使用化学洗涤剂清洁蔬菜水果和餐具的频率越高(OR为1.163)等4个因素为哮喘发病的危险因素,而儿时接种过疫苗(OR为0.886)及儿时母乳喂养超过6个月(OR为0.858)是哮喘的保护因素。结论支气管哮喘可能是生活方式、生活环境和遗传因素共同作用而导致的一种疾病。Objective To explore the correlative causes of bronchial asthma. Methods The study adopted group case-control method and questionnaire survey to analyze the correlative causes of bronchial asthma. Results The results of single-factor Logistic re- gression analysis included ten factors were to be related to asthma, and six factors in multiple-factors Logistic regression model. The risk factors causing bronchial asthma included cars per family （ OR = 2. 901 ）, hair dyeing at least once in the last 10 years （ OR = 2. 620 ） , paternal or maternal relatives suffering from allergic diseases （ OR = 1. 225 ）, and the higher use frequency of chemical detergents to clean fruits and vegetables and cutlery （OR = 1. 163 ）. The protective factors were vaccination during childhood （OR = 0. 886 ） and breastfeed time more than 6 months in childhood （ OR = 0. 858 ）. Conclusion Bronchial asthma may be caused by multiple-factors such as lifestyle, environment and hereditary factors.

关 键 词：支气管哮喘 相关因素 病例对照研究 LOGISTIC回归分析 

分 类 号：R562.25[医药卫生—呼吸系统]