PS对早产儿外周血T淋巴细胞和NK细胞的影响  

Explore the Effect of Exogenous Surfactant Therapy on Levels of T Lymphocytes and NK Cells in Peripheral Blood

作　　者：董建敏 安丽[2] 

机构地区：[1]山东省肥城市人民医院儿科,271600 [2]山东大学附属济南市中心医院儿科,250013

出　　处：《中华全科医学》2013年第2期177-178,共2页Chinese Journal of General Practice

基　　金：山东省自然科学基金项目(Y2010C37)

摘　　要：目的探讨外源性肺表面活性物质的应用对早产儿外周血T淋巴细胞和NK细胞的影响。方法选择2011年1月-2012年1月应用肺表面活性物质(pulmonary surfactant,PS)治疗的早产儿共30例,测定其应用PS前、应用后3 d血清内SP-A、SP-D,和外周血T淋巴细胞亚群和NK细胞的活性,并以健康足月儿6名为对照组。结果①早产儿应用PS前,血清SP-A、SP-D、CD3+、CD4+、CD16+CD56+比值均低于对照组,差异有统计学意义(P<0.05);而CD4+/CD8+高于对照组;②早产儿应用PS后3天SP-A、SP-D、CD3+、CD4+、CD16+CD56+及CD4+/CD8+比值均有明显升高,差异有统计学意义(P<0.05)。结论应用外源性肺表面活性物质可有效提高早产儿外周血NK细胞数量及CD4+/CD8+比值。Objective To investigate the effect of Exogenous Surfactant Therapy on Levels of T lymphocytes and NK ceils in peripheral blood in preterm infants who were treated with exogenous pulmonary surfactants （exPS）. Methods From Jan 2011 to Jan 2012,30 cases of preterm infants who were treated with exPS, selected over the same period 6 cases of full-term healthy in-fants, peripheral blood T lymphocytes and NK cells were detected and compared. Results The results showed that SP-A, SP-D, CD3^＋ , CD4^＋ , NK, and the ratio of CD4^＋/CD8^＋ in preterm infants were lower than those in the control group（ P 〈 0.05 ）. All of those in post-surfactant were significantly higher than those in pre-surfactant （ P 〈 0.05 ）. Conclusion In preterm infants, treat-ment with exPS can apparently stimulate the innate host defense systems.

关 键 词：肺表面活性物质 NK细胞 SP—A SP—D 

分 类 号：R722.6[医药卫生—儿科] R392.12[医药卫生—临床医学]