参与小RNA病毒感染和复制的宿主及病毒蛋白功能研究进展  

Progress on the functions of host and viral proteins participated in picornavirus infection and replication

作　　者：魏衍全[1] 郭慧琛[1] 徐进[1] 孙德惠[1] 孙世琪[1] 

机构地区：[1]中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室/农业部畜禽病毒学重点开放实验室,兰州730046

出　　处：《中国人兽共患病学报》2013年第1期82-85,90,共5页Chinese Journal of Zoonoses

基　　金：国家自然科学基金(31100688,31101838);甘肃省科技重大专项(1102NKDA033,1102NKDA034);甘肃省国际科技合作计划项目(1104WCGA185)~~

摘　　要：阐明宿主和病毒间的相互作用对于理解病毒的复制、致病性和毒力至关重要,本文对小RNA病毒感染和复制过程中参与的宿主蛋白和病毒蛋白的功能最新研究进展做一综述。首先讨论病毒衣壳蛋白和宿主细胞受体间的相互作用,然后详述病毒复制过程中参与的病毒蛋白和宿主细胞蛋白。Understanding of the interaction between the host and the virus is essential to viral replication, pathogenicity and virulence. The article gives an overview of progress on the functions of host and viral proteins that are participated in picor- navirus infection and replication. Firstly the interactions of viral capsid proteins with host cell receptors had been discussed, and then the viral and host cell proteins that are participated in picornavirus replication had been elucidated. To illuminate how cellular proteins interact with viral proteins or viral RNA will provide insights for the design of novel antiviral agents based on these interactions.

关 键 词：小RNA病毒 感染与复制 病毒及宿主蛋白 

分 类 号：Q71[生物学—分子生物学]