局部振动对家兔血浆内皮素浓度的影响  

Effects of local vibration on the concentration of plasma endothelin in rabbits

作　　者：林立[1] 张春之[1] 聂继池[1] 张强[1] 王林[1] 

机构地区：[1]济宁医学院职业卫生与环境医学研究所,272013

出　　处：《中华劳动卫生职业病杂志》2000年第3期137-139,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：山东省自然科学基金!资助项目 (Y96c0 10 2 3)

摘　　要：目的　探讨局部振动对血浆内皮素浓度的影响及其与振动性血管损伤之间的关系。方法　将家兔随机分为A组 (接振强度 4.90m/s2 )、B组 (接振强度 15 .31m/s2 )、C组 (接振强度 2 6 .2 6m/s2 )和 1个对照组 ,分别于不同接振时间测定各组家兔血浆内皮素浓度。结果　接振后 10、2 0、30d ,A组的血浆内皮素浓度分别为 (4 5 .71± 3.6 2 )pg/ml、(5 1.97± 4.46 )pg/ml、(5 5 .37± 5 .5 3)pg/ml;B组分别为 (5 2 .5 6± 8.0 0 )pg/ml、(6 3.2 4± 6 .73)pg/ml、(72 .98± 9.2 4)pg/ml;C组分别为 (6 4.77± 5 .0 8)pg/ml、(83.6 4± 9.36 )pg/ml、(82 .5 6± 6 .41)pg/ml。随接振时间的延长和接振剂量的增大 ,血浆内皮素浓度有升高的趋势 ,振动试验后 ,各试验组血浆内皮素浓度均高于对照组 ,差异有显著性 (P <0 .0 5 ,P <0 .0 1)。结论　局部振动可致家兔血浆内皮素浓度增高 。Objective To study the effects of local vibration on the concentration of plasma endothelin(ET) in rabbits and the relation between it and vibration induced vascular impairment(VVI). Methods The concentration of plasma ET was measured and analyzed in rabbits with different vibration power(A group:4.90 m/s 2,B group:15.31 m/s 2,C group:26.26 m/s 2) and different expoure period. Results After exposure to vibration for 10,20,30 days,the concentration of plasma ET were (45.71±3.62) pg/ml, (51.97±4.46)pg/ml,(55.37± 5.53) pg/ml respectively in A group;(52.56±8.00)pg/ml,(63.24±6.73)pg/ml,(72.98±9.24)pg/ml in B group; (64.77 ±5.08)pg/ml,(83.64±9.36)pg/ml,(82.56±6.41)pg/ml in C group.As the vibration exposure time and vibration power increased,there was a rising tendency in the concentration of plasma ET in the experimental groups.The concentration of plasma ET in all experimental groups increased higher than that in control group( P <0.05, P <0.01). Conclusion Local vibration could result in increasing of plasma ET in rabbits,which may have certain relations with VVI.

关 键 词：局部振动 内皮素 振动性血管损伤 

分 类 号：R135.1[医药卫生—劳动卫生]