尿微量清蛋白与尿肌酐比值对妊娠期糖尿病早期肾损伤的诊断价值  

Values of urinary albumin and creatinine ratio for early diagnosis of renal injury in patients with gestational diabetes mellitus

作　　者：周远青[1] 梁瑞莲[1] 谢健敏[1] 梁玉全[1] 刘传桂 吴建辉[1] 张婷[3] 罗建伟[1] 

机构地区：[1]南方医科大学附属顺德第一人民医院检验科,广东顺德528300 [2]广东省佛山市顺德区均安医院,528329 [3]南方医科大学附属顺德第一人民医院产科,广东顺德528300

出　　处：《国际检验医学杂志》2012年第15期1803-1805,共3页International Journal of Laboratory Medicine

基　　金：佛山市科技局医学类科技攻关项目(201108257);佛山市卫生局医学科研立项课题(2011474)

摘　　要：目的探讨随机尿微量清蛋白/尿肌酐比值(UmAlb/UCr)在妊娠期糖尿病(GDM)肾损伤早期诊断的应用价值。方法收集59例正常妊娠妇女和66例GDM患者,并选取50例非妊娠健康育龄妇女作为健康对照组,检测各组随机尿UmAlb/UCr值、血清肌酐(Scr)和尿素(Urea)。结果对各组检测结果进行统计分析,比较各组差异,统计工具采用SPSS17.0统计软件。结果 GDM组、正常妊娠组和健康对照组的尿UmAlb/UCr检测结果分别为(12.02±16.70)、(1.83±0.50)、(1.86±0.45)mg/mmol,Scr检测结果分别为(81.43±37.58)、(58.34±12.01)、(55.79±10.04)μmol/L,Urea检测结果分别为(7.71±4.38)、(4.78±1.23)、(4.93±1.34)mmol/L。GDM组的UmAlb/UCr、Scr和Urea结果与正常妊娠组和健康对照组比较差异有统计学意义(P<0.01),正常妊娠组和健康对照组比较差异无统计学意义(P>0.05)。GDM组的UmAlb/UCr、Scr和Urea检测阳性率分别为39.4%、25.8%和22.7%,GDM组的UmAlb/UCr检测阳性率高于Scr和Urea,差异有显著性意义(P<0.05)。结论随机UmAlb/UCr比值可作为GDM肾损伤早期诊断的敏感指标。Objective To study the early diagnosis value of urinary albumin and creatinine ratio（UmAlb/UCr） for renal injures in patients with gestational diabetes mellitus（GDM）.Methods 58 cases normal pregnant women,66 cases GDM patients and 50 cases of healthy controls were collected in the study.Random urine UmAlb/Ucr,serum Scr and Urea of the each group were detected.Statistical analysis were performed with SPSSl7.0 statistical software.Results The testing results of the GDM group,the normal pregnancy group and the control group were as follows,UmAlb/UCr：（12.02±16.70）,（1.83±0.50） and（1.86±0.45）mg/mmol,Scr：（81.43±37.58）,（58.34±12.01） and（55.79±10.04）μmol/L,Urea：（7.71±4.38）,（4.78±1.23） and（4.93±1.34） mmol/L.There were significant differences in the comparison of UmAlb/UCr,Scr and Urea among the GDM group,the normal pregnancy group and the control group（P0.01）.There were no significant differences in the comparison of UmAlb/UCr,Scr and Urea between the normal pregnancy group and the control group（P0.05）.In the GDM group,the positive rate of UmAlb/UCr,Scr and Urea were 39.4%,25.8% and 22.7%,respectively.The positive rate of UmAlb/UCr was higher than that of Scr and Urea in the GDM group,and the differences had statistic significance（P0.05）.Conclusion UmAlb/UCr could be used as early diagnostic indicator for renal injury in GDM patients.

关 键 词：糖尿病 妊娠 微量清蛋白 肌酐 肾损伤 

分 类 号：R714.25[医药卫生—妇产科学]