110例丙肝患者HCV-RNA载量及抗-HCV与肝功能指标的相关性研究  

Study on correlation between HCV-RNA quantity and anti-HCV as well as liver function index

作　　者：黄秀琼[1] 吴英[1] 

机构地区：[1]广东佛山市中医院检验科,528000

出　　处：《国际检验医学杂志》2012年第15期1809-1810,共2页International Journal of Laboratory Medicine

摘　　要：目的研究丙型病毒性肝炎(简称丙肝)患者血清HCV-RNA含量及抗-HCV与ALT、AST浓度的关系。方法采用实时荧光定量PCR法检测110例患者的血清HCV-RNA,ELISA法检测抗-HCV,全自动生化分析仪检测ALT、AST。结果丙肝患者抗-HCV滴度显著高于健康对照组,大部分患者的ALT、AST水平均有显著性上升;HCV-RNA含量与ALT、AST水平有显著相关性,而与抗-HCV的S/CO值无显著相关性。结论 HCV-RNA和抗-HCV检测与肝功能指标各有利弊,三者结合起来在早期准确诊断及监测疗效中具有重要意义和价值。Objective To study relationship between the HCV RNA,anti-HCV levels as well as ALT and AST levels.Methods The serum HCV RNA was tested by real-time fluorescent quantitative assay,anti-HCV by ELISA,ALT and AST by enzyme-rate method in samples from 110 cases of hepatitis C patients.Results Anti-HCV serum antibody titers in hepatitis C patients were significantly higher than that in the control group,and the ALT and AST levels were significantly increased in the majority of patients.HCV RNA and ALT,AST levels were significantly correlated but HCV RNA and anti-HCV had no significant correlation.Conclusion Each index of HCV RNA,anti-HCV,ALT and AST has advantages and disadvantages in the diagnosis and therapy of HCV infection.The right combination of these indexes has important clinical significance in the diagnosis,prediction of liver injury and efficacy of early treatment.

关 键 词：肝炎 丙型 RNA 病毒 肝炎抗体 丙型 丙氨酸转氨酶 天冬氨酸氨基转移酶 

分 类 号：R512.63[医药卫生—内科学]