56例反复自然流产患者外周血中CD94含量及相关性分析  

Analysis the correlation and significance between CD94 and recurrent spontaneous abortion

作　　者：洪玉环[1] 纪官治[1] 翁宝钏[1] 

机构地区：[1]福建省厦门市第三医院检验科,361100

出　　处：《国际检验医学杂志》2012年第15期1830-1831,共2页International Journal of Laboratory Medicine

摘　　要：目的探究外周血中CD94在反复自然流产(RSA)患者体内的含量变化及关系。方法本院2008年1月至2011年4月56例RSA未孕35例患者设为观察A组,自然流产次数超过3次,排除感染、染色体异常等因素;30例RSA已孕但被确诊为难免流产患者设为观察B组;同期30例正常妊娠早孕人工流产患者设为对照组,既往无流产史,超声检查证实宫内孕单活胎。对三组患者进行CD94指标的检测,对比三组患者外周血中的CD94的表达水平。结果本研究发现CD94在三组患者外周血中均有表达,含量观察组表达率明显低于对照组(P均<0.05)。结论 CD94含量在外周血中的低表达可能与反复自然流产的发病和病理生理过程有关。Objective To investigate the correlation and significance between CD94 and recurrent spontaneous abortion（RSA）.Methods The patients were selected from January 2008 to April 2011,including RSA non-pregnancy group for 35 cases（group A）,with the number of abortions at least for 3 times,without eliminating the factors of chromatosome,anatomy,endocrine,infection and embryo deformity,RSA pregnancy group for 30 cases（group B）,with diagnosis of inevitable abortion,and normal pregnancy group for 30 cases（control group）,with artificial abortion and without history of informal pregnancy and the above diseases.CD94 levels in the three groups were compared.Results CD94 could be detected in peripheral blood in the three groups,and those in observation groups were significantly lower than in control group（P0.05）.Conclusion Lower expression level of CD94 might play an important role in pathogenesis of RSA,which could be used as a parameter for determining individuals at risk.

关 键 词：流产 自然 自然杀伤细胞 抗原 CD94 

分 类 号：R714.21[医药卫生—妇产科学]