口腔鳞状细胞癌发生发展过程中P^(21wafl)表达的研究  

A study on Expression of P^(21wafl) in Genesis of Oral Squamous Cell Carcinoma

作　　者：何国斌[1] 姜育红[1] 赵红宇[2] 韩萌 裴迎宾[2] 李新明[2] 石爱梅[2] 

机构地区：[1]河南医科大学口腔系,450052 [2]河南医科大学第一附属医院口腔科,450052 [3]郑州市口腔医院,450053

出　　处：《口腔医学》2000年第2期66-67,共2页Stomatology

基　　金：河南省教委科技攻关项目!基金资助编号 :9881 1 70 80 7

摘　　要：目的 :了解P2 1wafl表达与口腔鳞状细胞癌发生发展的关系。方法 :利用免疫组化技术 ,进行石蜡切片回顾性研究。结果 :P2 1wafl蛋白在口腔上皮单纯增生的表达率为 75 % (12 / 16 ) ,显著高于口腔不典型增生 (2 6 0 9% ,6 / 2 3) ((p <0 0 5 )和鳞状细胞癌 (2 8 2 6 % ,13/ 46 ) (p<0 0 5 ) ;P2 1wafl阳性标本的阳性细胞计数与组织恶性程度成正相关。结论 :P2 1wafl表达的下调是口腔鳞癌发生发展过程中较早期事件 ,P2 1wafl表达率结合P2 1wafl阳性细胞计数在口腔粘膜癌前病变监视方面是一项有用的指标。Aim:To investigate the relationship between expression of P 21wafl and genesis of oral squamous cell carcinoma Methods:A retrospective study on paraffin-embedded specimens with immunohistochemical technique.Results:P 21wafl -positive rate in oral simple hyperplasia was 75%(12/16)which was significantly higher than in oral dysplasia(26.09%,6/23)(p<0 05) and in oral squamous cell carcinoma(28.26%,13/46)(p<0 05).P 21wafl -positive cell counting was positively associated with the malignancy progressior of oral mucosa lesions.Conclusion:The down-regulation of P 21wafl expression is an early event in carcinogenesis of and mucosa,P 21wafl -positive rate oral P 21wafl -positive cell counting combined can serve as a indicator for malignant transition of oral precancerous lesions. [WT5”FZ]

关 键 词：单纯增生 不典型增生 鳞状细胞癌 口腔肿瘤 

分 类 号：R739.802[医药卫生—肿瘤]