艾叶多糖对促红细胞生成素体内作用的影响  

Influence of Artemisia argyi polysaccharide on the in vivo effects of erythropoietin

作　　者：李仲娟[1,2] 杨朝令[1] 喻昕[1] 喻格书[1] 汪宏良[2] 

机构地区：[1]湖北理工学院医学院,湖北黄石435003 [2]黄石市中心医院,湖北黄石435000

出　　处：《国际检验医学杂志》2012年第18期2193-2193,2195,共2页International Journal of Laboratory Medicine

基　　金：黄石理工学院创新团队项目(201025)

摘　　要：目的探讨艾叶多糖(APS)对促红细胞生成素(EPO)小鼠体内作用的影响。方法煌焦油蓝染色法计数网织红细胞(Ret)数量,血细胞分析仪检测平均血红蛋白含量(MCH)。结果小鼠年龄对EPO的作用影响较大,90d以上小鼠EPO的作用效果较为稳定;EPO对脾脏的刺激作用受APS影响较大;MCH可间接评价不同脏器对EPO作用的敏感性。结论 APS能促进EPO对脾脏和肝脏作用,Ret计数和MCH可用于评价EPO的作用。Objective To explore the influence of Artemisia argyi polysaccharide（APS） on the in vivo effects of erythropoietin （EPO） in mice. Methods Brilliant eresyl blue staining was used to count the number of retieuloeytes（Ret）. Automatic blood cell analyzer was used to detect mean corpuscular hemoglobin（MCH）. Results The effects of EPO were influenced by age of mice, which could be stable after 90 days old. Effects of EPO on spleen might be more sensitive to the influence of APS. MCH could be used for the evaluation of the sensitivity of target organs to EPO. Conclusion APS could enhance the effects of EPO on spleen and liver. Ret counting and MCH could be used to evaluate the effects of EPO.

关 键 词：艾叶多糖 促红细胞生成素 网状细胞 平均血红蛋白 

分 类 号：R285[医药卫生—中药学]