3-溴-4-氟硝基苯的合成  

SYNTHESIS OF 3-BROMO-4-FLUORONITROBENZENE

作　　者：王林[1] 董燕敏[1] 殷杰[1] 蒋锐[1] 杨金会[2] 赵天生[2] 陈兴权[1] 

机构地区：[1]常州大学石油化工学院,江苏常州213164 [2]宁夏大学能源化工重点实验室,宁夏银川750021

出　　处：《精细石油化工》2012年第6期1-4,共4页Speciality Petrochemicals

基　　金：国家自然科学基金(20962016)

摘　　要：采用无水醋酸作为溶剂,以对氟硝基苯为原料,1,3-二溴-5,5-二甲基海因(DBDMH)为溴代试剂,合成了3-溴-4-氟硝基苯。最佳反应条件为:n(对氟硝基苯):n(DBDMH)=1:0.51,以无水醋酸作溶剂,反应温度15℃,反应时间3 h,在此条件下3-溴-4-氟硝基苯的收率为98.7%。重复实验表明,该反应条件温和,反应易于控制,重复性好。3-Bromo-4-fluoronitrobenzene was prepared from 4 fluoronitrobenzene in the solvent of ace-tic acid, using 1,3-dibromo-5,5 dimethylhydantoin （DBDMH） as bromide reagent. The process is easy to be controlled with moderate reacting conditions. After quantitatively calculating for the GC re-sults of the target product, the optimal conditions were obtained. The yield could be up to 98. 7% when n（4-fluoronitrobenzene） ： n（DBDMH） = 1 ： 0.51, the reaction temperature was 15 ℃ and the reaction time was 3 h. The repeated experiments showed that the technology had a good repeatability under the above optimal conditions.

关 键 词：对氟硝基苯 溴代 3-溴-4-氟硝基苯 精细化工中间体 

分 类 号：TQ242.2[化学工程—有机化工]