PLGA／TPGS-姜黄素纳米粒的制备及体外评价  

Preparation and in Vitro Evaluation of Poly （Lactic-co-glycolic acid） /tocopheryl Polyethylene Glycol Succinate-curcumin Nanoparticles

作　　者：禤智东[1] 黄岳山[1] 

机构地区：[1]华南理工大学生物医学工程系,广东广州510006

出　　处：《纳米科技》2012年第6期44-49,共6页

摘　　要：以维生素E1000聚乙二醇琥珀酸酯（TPGS）为乳化剂，姜黄素为模型药物，聚乳酸-羟基乙酸为载体材料，采用O／W型乳化-溶剂挥发法制备聚乳酸-羟基乙酸-姜黄素纳米粒，以包封率和载药量为主要指标，单因素实验探索影响两指标的主要因素，正交试验设计优化制备工艺，结果表明，制备聚乳酸-羟基乙酸-姜黄素纳米粒的最佳工艺为：聚合物浓度4％，乳化剂TPGS浓度0．03％，超声时间8min，搅拌时间6h。以此工艺制备的载药纳米粒外形圆整光滑，粒度分布较为均匀，平均粒径为189．7nm，包封率为86．2％，载药量为7．45％。Using Vitamin El000 and Polyethylene glycol succinate（TPGS） as emulsifier, curcumin as a model drug, poly-lactic acid-glycolie acid carrier material, eurcumin loaded poly （lactic-co-glyeolic acid）（PLGA） nanoparticles were prepared by an O/W emulsion-solvent evaporation method. The ER and DL were used as the main indicators. Singe factor test was used in order to find the effect of all kinds of parameters on the NP＇s preparation, and then NP＇s formulations were optimized by orthogonal design test. The results indicate that the optimal preparation conditions determined by or- thogonal experiment are as follows： polymer concentration 4%, the emulsifier TPGS concentration of 0.03%, ultrasonic time of 8min, stirring time 6h. The drug-loaded nanoparticles＇ER was 86.2%, the DL was 7.45% and the mean diameter was 189.7nm.

关 键 词：姜黄素 聚乳酸-羟基乙酸 纳米粒 正交实验 

分 类 号：TB34[一般工业技术—材料科学与工程]