当归对肝损伤模型小鼠部分糖代谢指标的影响  

Effects of Angelica on Some Glucose Metabolism Indexes in Liver Injury Models of Mice

作　　者：吕锦芳[1] 冯保明[1] 宁康健[1] 应如海[1] 姜锦鹏[1] 

机构地区：[1]安徽科技学院动物科学学院,安徽凤阳233100

出　　处：《安徽科技学院学报》2012年第6期10-13,共4页Journal of Anhui Science and Technology University

基　　金：安徽科技学院重点学科建设项目(AKXK20101-2)

摘　　要：50只小鼠随机分成5组,Ⅰ～Ⅴ组分别对照组、肝损伤模型组和当归剂量组(低、中、高剂量)。Ⅲ～Ⅴ组分别按5g/kg、10g/kg、20g/kg皮下注射当归注射液,Ⅰ、Ⅱ组注射等量的生理盐水,连续5d。末次给药后2 h,Ⅱ～Ⅴ组腹腔注射0.1%四氯化碳石蜡油溶液(10mL/kg),24 h后处死小鼠测定肝指数、血糖水平和肝糖原、肌糖原含量。结果表明,模型组及当归各剂量组的小鼠肝指数与对照组差异不显著(P!0.05)。模型组血糖水平显著降低,肝糖原、肌糖原含量显著提高(P"0.01),低、中剂量的当归表现对抗作用,低剂量作用显著(P"0.01)。表明肝损伤模型小鼠部分糖代谢指标出现异常变化,低剂量的当归对此具有明显的保护作用。50 mice were randomly divided into five groups which were： control group, liver injury model group and An- gelica low, middle, high - dose group. Angelica Injection of 5g/kg, 10g/kg, 20g/kg were given by subcutaneous in- jection at the Ⅲ- Vgroups respectively, and I ～ Ⅱ groups were injected the same amount of equal saline one time a day for five days. At last injected for two hours,Ⅱ- Vgroups were all injected by intraperitoneal with paraffin oil solu- tion of carbon tetrachloride at 0. 1% （10mL/kg body weight）, then the mice were sacrificed for 24 hours and liver in- dex, serum glucose, content of liver glycogen and muscle glycogen were measured. Results： There were no difference at liver index of the model group and the doses of Angelica groups than that of the control group （P 〉 0.05）. The lev- el of serum glucose was significantly decreased at model group （P 〈 0.01 ）, which content of liver glycogen and mus- cle glycogen were significantly increased（P 〈0.01）, while the low, middle doses of Angelica did appear to antago- nism and low dose＇s effects were all significant（P 〈0.01）. It is indicated that the some glucose metabolism indexes has abnormal changes in liver injury model of mice, and low dose of Angelica has obvious protective effects to it.

关 键 词：小鼠 当归 血糖 肝糖原 肌糖原 

分 类 号：R285.5[医药卫生—中药学]