In vitro Degradation Study of a Braided Thin-Walled Biodegradable Ureteral Stent  

作　　者：尚亚峰 邹婷 张明庆 王富军 周君梅 王文祖 谢华 王璐 陈方 

机构地区：[1]Department of Urology,Shanghai Children's Hospital,Shanghai Jiaotong University School of Medicine [2]Key Laboratory of Textile Science & Technology,Ministry of Education,College of Textiles,Donghua University

出　　处：《Journal of Donghua University(English Edition)》2012年第5期385-388,共4页东华大学学报（英文版）

基　　金：Program for Outstanding Medical Academic of Shanghai,China (No. LJ10016);Joint Key Project for the New Technology of Shanghai Municipal Hospital,China (No. SHDC12010108);111 Project"Biomedical Textile Materials Science and Technology",China (No.B07024);Doctoral Fund of Ministry of Education of China (No. 20100075110001)

摘　　要：The main disadvantage of conventional ureteral stents commonly used to provide urinary drainage after urological practice is that the patients have to undergo a secondary surgical procedure to remove stents. A new braided thin-walled biodegradable ureteral stent composed of PGA （ polyglycolic acid） and PLGA （ eopolymer of polylactic and polygiycolic acid） mnltifilaments was evaluated in v/tro in this study. In vitro degradation was performed in artificial urine with pH of 5.8 and the temperature of 37~C. The mass loss, mechanical properties, and morphology were observed at different degradaing time intervals of 0, 1, 2, 3, 4, and 5 weeks. The stent had a thinner wail than those of other degradable stents and provided better mechanical properties. The braided thin-walled biodegradable ureteral stents began to degrade after 2 weeks. At the week of 5, the stents were fully degraded. The degradative process of stents is smooth and well controlled.The main disadvantage of conventional ureteral stents commonly used to provide urinary drainage after urological practice is that the patients have to undergo a secondary surgical procedure to remove stents. A new braided thin-walled biodegradable ureteral stent composed of PGA (polyglycolic acid) and PLGA (copolymer of polylactic and polyglycolic acid) multifilaments was evaluated in vitro in this study. In vitro degradation was performed in artificial urine with pH of 5.8 and the temperature of 37℃. The mass loss, mechanical properties, and morphology were observed at different degradaing time intervals of 0, 1, 2, 3, 4, and 5 weeks. The stent had a thinner wall than those of other degradable stents and provided better mechanical properties. The braided thin-walled biodegradable ureteral stents began to degrade after 2 weeks. At the week of 5, the stents were fully degraded. The degradative process of stents is smooth and well controlled.

关 键 词：braided THIN-WALLED degradable ureteral stent PGA（polyglycolic acid） PLGA （ copolymer of polylactic and polyglycolicacid） in vitro degradation mechanical property 

分 类 号：R608[医药卫生—外科学]