PCT与hs-CRP在新生儿炎症性疾病中的比较  

Clinical analysis on PCT and hs-CRP in neonatal inflammatory diseases

作　　者：陈平[1] 刘健[1] 李海珠[1] 谭尚华[1] 莫燕芳[1] 梁梅芳[1] 

机构地区：[1]肇庆市第一人民医院,广东肇庆526021

出　　处：《实验与检验医学》2012年第6期601-603,共3页Experimental and Laboratory Medicine

摘　　要：目的评价血清降钙素原(PCT)与超敏C反应蛋白(hs-CRP)在新生儿全身细菌感染与病毒感染等疾病中的诊断价值,及在临床监测的应用。方法120例新生儿患者分为细菌感染组、病毒感染组和非感染性疾病组,采用电化学发光免疫分析测定血清中的PCT,微粒增强免疫透射比浊法测定hs-CRP;细菌感染组治疗后两天再次检测PCT。结果以血清PCT>0.5ng/ml为阳性标准,细菌感染组阳性率为98%,病毒感染组为10%,非感染性疾病组为10%,细菌感染组与其他两组比较有显著性差异(P<0.01)。以hs-CRP>10mg/L为阳性标准,细菌感染组阳性率为58%,病毒感染组为48%,非感染性疾病组为35%,细菌感染组与病毒感染组无显著性差异(P>0.05);细菌感染组治疗后PCT显著下降(P<0.05)。结论血清PCT检测可用于新生儿细菌感染诊断与鉴别诊断,对于细菌感染的疗效监测也非常有效。Objective To evaluate the clinical significance of serum procalcitonin（PCT） and high-sensitivity C-reactive protein（hs-CRP） in the diagnosis of neonatal inflammatory diseases infected with bacterium and virus.Methods A totalof 120 subjects,including bacterial infection,virus infection and non-infectious disease were enrolled in this study.PCT was determined by chemiluminescence immunoassay and hs-CRP was measured by nephelometry.After two days of post-treatment,the serum procalcitonin was determined again in bacterial infection group.Results When the cutoff was 0.5ng/ml,the positive rate of PCT in the neonatal inflammatory diseases group with bacterial infection was 98%,which was much higher than other group（P0.01）.When the cutoff was 10mg/L,the positive rate of hs-CRP was no significant difference in the three groups.The levels of PCT dropped significantly with bacterial infection of post-treatment.Conclusion Determination of serum PCT could provide more accurate diagnostic evidence in neonatal inflammatory diseases and monitor response to therapy.

关 键 词：降钙素原 超敏C反应蛋白 新生儿感染性疾病 细菌感染 病毒感染 

分 类 号：R722.13[医药卫生—儿科] R446.62[医药卫生—临床医学]