NOS1AP基因多态性与2型糖尿病发病风险关联分析  

Analysis on the association between NOS1AP gene polymorphism and risk of type 2 diabetes meUitus

作　　者：翟云鹏[1] 高杏[1] 李伟[2] 吕冬梅[3] 王艳[3] 王涛[1] 魏雅琴[1] 吴云明[1] 印晓星[1] 

机构地区：[1]徐州医学院新药与临床应用实验室,江苏徐州221002 [2]徐州医学院附属医院内分泌科,江苏徐州221002 [3]徐州医学院附属医院药剂科,江苏徐州221002

出　　处：《徐州医学院学报》2012年第12期811-814,共4页Acta Academiae Medicinae Xuzhou

基　　金：基金项目：江苏省高校优势学科建设工程项目

摘　　要：目的探讨一氧化氮合酶1转接蛋白（NOS1AP）基因多态性与中国淮海地区汉族人群2型糖尿病发病风险的关系。方法采用聚合酶链式反应一限制性片断长度多态性（PCR—RFLP）方法对200例2型糖尿病患者（病例组）和200例健康人群（对照组）进行NOS1AP基因多态性检测。结果病例组NOS1APrs12742393位点CC基因型和C等位基因频率均高于对照组（P〈0．05），C等位基因显著增加2型糖尿病的遗传风险性（OR=1．662，95％CI=1．089～2．535，P=0．018）。结论NOS1APrs12742393位点多态性可能与中国淮海地区汉族人群2型糖尿病的发病相关，C等位基因可能是2型糖尿病的遗传风险因子。Objective To investigate the correlation between nitric oxide synthase 1 adaptor protein （NOS1AP） gene polymorphism and risk of type 2 diabetes mellitus in Chinese Han population from Huaihai region. Methods The gene polymorphisms of 200 type 2 diabetes mellitus patients （case group） and 200 healthy subjects （control group） were detected by polymerase chain reaction - restriction fragment length polymorphism （ PCR - RFLP）. Results CC genotype frequency and C allele frequency of NOS1AP rs12742393 in case group were higher than those in control group （P 〈 0.05）. There was significantly difference between the two groups. The C allele significantly increased the genetic risk of type 2 diabetes mellitus （ OR = 1. 662, 95% CI = 1. 089 - 2. 535, P = 0. 018）. Conclusions NOS1AP rs12742393 pol- ymorphism may be associated with the incidence of type 2 diabetes mellitus among Chinese Han population from Huaihai region, C allele may be the genetic risk factor for type 2 diabetes mellitus.

关 键 词：2型糖尿病 基因多态性 一氧化氮合酶1转接蛋白 

分 类 号：R394.5[医药卫生—医学遗传学] R587.1[医药卫生—基础医学]