视黄醇结合蛋白在糖尿病早期肾病诊断中的效果评价  

Evaluation of the effect of retinol-binding protein on the diagnosis of early diabetic nephropathy

作　　者：张益红[1] 潘明麟[1] 徐家蓉[1] 游娜[1] 叶小龙[1] 

机构地区：[1]南京医科大学第二附属医院,江苏南京210011

出　　处：《安徽医学》2012年第12期1634-1636,共3页Anhui Medical Journal

摘　　要：目的探讨视黄醇结合蛋白(RBP)在糖尿病早期肾病诊断中的意义。方法选择101例2型糖尿病住院患者为研究对象,建立模型0(仅包括基本资料年龄、性别、BMI、血脂等),模型1(基本资料+常规肾功能指标BUN、Cr、UA)和模型2(基本资料+RBP)等3个模型,采用Logistic回归及受试者工作特征曲线(ROC曲线),基于曲线下(AUC)面积评价RBP在诊断是否患有糖尿病早期肾病中的效果。结果模型0,模型1和模型2等3个模型的AUC面积的差异具有统计学意义(AUC0=73.99%,AUC1=76.09%,AUC2=87.39%,P=0.0077)。模型2的AUC明显高于模型1及模型0(P2vs1=0.0058,P2vs0=0.0019):而模型1和模型0的AUC差异无统计学意义(P=0.33)。结论 RBP在诊断糖尿病早期肾病方面较之BUN、Cr等传统肾功能指标相比,具有更好的诊断效果。Objective To investigate the effect of retinol - binding protein （RBP） on the diagnosis of early stage diabetic nephropathy. Methods All 101 cases of type 2 diabetes admitted in our hospital in 2012 were included in this research. Model 0 （ including baseline information： age, sex, BMI and sermn lipid level）, model 1 （including baseline information plus common renal function index： BUN, Cr and UA） and model 2 （including baseline information plus RBP） were set up. Logistic regression and the area under curve （AUC） statistic of receiver operating characteristic （ ROC ） curve was used to detect the application effect of RBP on the diagnosis of early stage diabetic nephropathy. Results The AUCs of model 0 , model 1 and model 2 were different with statistical significance （AUC0 =73.99% ,AUCl =76. 09% , AUC2 = 87.39% ,P = 0. 0077）. The AUC2 was statistically higher than AUC1 and AUC0 （ P2vs1 = 0. 0058, P2vs0 = 0. 0019 ）. While there was no significant difference between AUCL and AUC0 （ P = 0. 3300 ）. Conclusion Compared with common renal function indicators, RBP is a better biomarker of early stage diabetic nephropathy.

关 键 词：视黄醇结合蛋白 糖尿病早期肾病 诊断 

分 类 号：R587.2[医药卫生—内分泌]