2型糖尿病患者血清缺氧诱导因子-1α与颈动脉粥样斑块的相关性  

Relationship between serum hypoxia-inducible factor-1α and carotid plaque in patients with type 2 diabetes mellitus

作　　者：鄂维琴[1] 施毕旻[1] 

机构地区：[1]苏州大学附属第一医院内分泌科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2012年第6期830-832,864,共4页Suzhou University Journal of Medical Science

基　　金：苏州市科技发展计划(应用基础研究)项目(SYS201022)

摘　　要：目的观察2型糖尿病(T2DM)患者血清缺氧诱导因子-1α(HIF-1α)的变化,探讨其与动脉粥样硬化性大血管病变的关系。方法选择32例T2DM合并颈动脉斑块患者(T2DM+CP组),24例单纯T2DM患者(T2DM组),24名健康体检者(正常对照组),采用酶联免疫吸附法(ELISA法)测定血清HIF-1α浓度。结果 T2DM+CP组和T2DM组HIF-1α水平均显著高于正常对照组(均P<0.01),T2DM+CP组HIF-1α水平明显高于T2DM组(P<0.05)。血清HIF-1α水平与空腹血糖、糖化血红蛋白C(HbA1c)、胰岛素抵抗指数(HOMA-IR)成明显正相关(均P<0.05)。多元线性逐步回归分析表明,HbA1c是血清HIF-1α水平的独立影响因素。结论 T2DM患者体内高水平的血清HIF-1α与血糖、胰岛素抵抗有关,在大血管并发症的发生发展过程中起着重要的作用。Objective To observe the changes of type 2 diabetes mellitus（T2DM） patients＇ serum hypoxia inducible factor-lot （HIF-1α）, and evaluate the relationship between serum HIF-1 ot and vascular lesions of atherosclerosis. Methods The serum level of HIF-1α in 32 T2DM with carotid plaques（T2DM ＋ CP group） , 24 T2DM without macrovascular complications （T2DM group）, and 24 controls was studied with ELISA method. Results The serum HIF-1α level in T2DM with and without carotid plaque group was significantly higher than that in the controls （ all P 〈 0.01 ）. Furthermore, among T2DM, the level of HIF-1α was higher in patients with carotid plaque than that without carotid plaque （P 〈 0.05 ）. The serum HIF-1α was positively correlated with fasting plasma glucose, HbA!c and HOMA-IR （all P 〈 0. 05 ）. Multiple linear stepwise regression analysis showed that HbAlc was the independent determinants of HIF-let. Conclusion High level of serum HIF-1α in T2DM patients concerns with blood glucose and insulin resist- ance, which plays an important role in the development of macrovascular complications.

关 键 词：2型糖尿病 缺氧诱导因子-1Α 颈动脉粥样斑块 

分 类 号：R587.1[医药卫生—内分泌]