冠状动脉介入治疗对肿瘤坏死因子α和基质金属蛋白酶-9水平的影响  

Influences of percutaneous coronary intervention on levels of tumor necrosis factor- α and matrix metalloproteinase-9

作　　者：刘丽军[1] 马燕霞[1] 信栓力[1] 常超[1] 李敏[1] 邵丽荔[1] 王晓丽[1] 朱洁莹[1] 李雅琪[1] 代艳君[1] 

机构地区：[1]河北省邯郸市第一医院心内科,邯郸056002

出　　处：《中国循证心血管医学杂志》2012年第6期527-528,共2页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：河北省医学科学研究重点课题计划(07150)

摘　　要：目的观察经冠状动脉介入治疗(PCI)治疗对肿瘤坏死因子α(TNF-α)及基质金属蛋白酶-9(MMP-9)的影响。方法纳入存在单支病变经PCI治疗的冠心病患者60例,同期经冠状动脉造影证实冠状动脉正常者30例作为对照组。分析两组冠心病危险因素的合并比例,采用酶联免疫吸附法分别检测入选患者冠状动脉介入治疗前后TNF-α和MMP-9水平并进行组间比较。结果①有冠状动脉狭窄需行PCI治疗患者存在冠心病危险因素的比例高于对照组;②PCI组患者术后血浆TNF-α显著高于术前[(19.89±5.41)ng/mLvs.(15.78±5.34)ng/ml,P<0.01],对照组冠状动脉造影术后TNF-α与术前相比差异无统计学意义[(13.76±5.54)ng/mLvs.(12.48±5.12)ng/mL,P>0.05];③PCI组患者术后血浆MMP-9显著高于术前[(21.97±5.93)mg/Lvs.(18.65±5.72)mg/L,P<0.01],对照组冠脉造影术后MMP-9与术前相比差异无统计学意义[(16.21±5.33)mg/Lvs.(15.31±5.21)mg/L,P>0.05]。结论需PCI治疗的患者冠心病危险因素高于无冠脉狭窄者,冠脉介入治疗较冠脉造影可造成冠心病患者血浆TNF-α及MMP-9水平明显升高,可能与术后支架再狭窄有关。Objective To count up the risk factors of coronary stenosis, and analyze the influences of percutaneous coronary intervention （ PCI ） on levels of plasma tumor necrosis factor- α（ TNF- α） and matrix metalloproteinase-9 （ MMP-9 ） in the patients with coronary heart disease （ CHD ） . Methods The patients （ n =60 ） with single vessel disease treated with PCI were selected as PCI group, and other subjects （ n =30 ） with normal coronary artery confirmed by coronary angiography （ CAG ） as control group. The merger ratio of CHD risk factors was counted up and analyzed in two groups. The levels of plasma TNF- α and MMP-9 were detected by using enzyme-linked immunosorbent assay （ ELISA ） before and after PCI. Results ① The ratio of risk factors was higher in PCI group than that in control group. ② The level of plasma TNF- α was significantly higher after PCI than before in PCI group [ （ 19.89 ± 5.41 ） ng/mL vs. （ 15.78 ± 5.34 ） ng/ml, P 0.01], while it had no significance in the difference before and after CAG in control group [ （ 13.76 ± 5.54 ） ng/mL vs.（ 12.48 ± 5.12 ） ng/mL, P 0.05]. ③ The level of plasma MMP-9 was significantly higher after PCI than before in PCI group [ （ 21.97 ± 5.93 ） mg/L vs . （ 18.65 ± 5.72 ） mg/L, P 0.01], while it had no significance in the difference before and after CAG in control group [ （ 16.21 ± 5.33 ） mg/L vs . （ 15.31 ± 5.21 ） mg/L, P 0.05]. Conclusion The risk factors are more in CHD patients needed to have PCI than those in subjects without coronary stenosis. PCI promotes more significantly the levels of plasma TNF- α and MMP-9 than CAG, which may be related to restenosis after stenting.

关 键 词：冠心病 肿瘤坏死因子Α 基质金属蛋白酶-9 

分 类 号：R541.4[医药卫生—心血管疾病]