胺碘酮联合倍他乐克治疗室上性心动过速伴高血压的疗效  

Curative effect of amiodarone combining metoprolol on paroxysmal supraventricular tachycardia

作　　者：易辉[1] 梁晋川[1] 吴音[1] 于沛涛[2] 罗艳红[3] 

机构地区：[1]成都中医药大学附属医院,610072 [2]北京大学医学部,100191 [3]右江民族医学院,533000

出　　处：《中国循证心血管医学杂志》2012年第6期547-548,共2页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的观察胺碘酮联合倍他乐克在室上性心动过速()伴高血压中的临床效果。方法纳入PSVT患者160例,随机分为普罗帕酮组(n=40)、胺碘酮组(n=40)、倍他乐克组(n=40)和联合组(胺碘酮和倍他乐克联用,n=40),分析各组治疗PSVT的疗效以及对血压的影响。结果 4种治疗方案终止PSVT的有效率分别为:联合组95%,倍他乐克组90%,普罗帕酮组82.1%,胺碘酮81.1%;起效时间分别为:联合组8min,倍他乐克组8min,普罗帕酮组13.5min,胺碘酮16min。降压效果以联合组最为明显,其次为倍他乐克组和胺碘酮组,以普罗帕酮组最差。结论与普罗帕酮、胺碘酮、倍他乐克单药相比,胺碘酮和倍他乐克联合应用终止PSVT效果最佳,且降压效果最好。Objective To investigate the application effects of propafenone, amiodarone and metoprolol on paroxysmal supraventricular tachycardia （ PSVT ） and effect of combination of amiodarone and metoprolol. Methods The patients （ n =160 ） with PSVT were randomly divided into propafenone group, amiodarone group, metoprolol group and combining group （ amiodarone combining metoprolol, each n =40 ） . The curative effects and changes of blood pressure were analyzed in all groups. Results The effective rate and onset time for ending PSVT were, respectively, 95% （ 8 min ） in combining group, 90% （ 8 min ） in metoprolol group, 82.1% （ 13.5 min ） in propafenone group and 81.1% （ 16 min ） in amiodarone group. The effect of reducing blood pressure was the highest in combining group, secondary higher in metoprolol group and amiodarone group, and the lowest in propafenone group. Conclusion Compared with propafenone, amiodarone and metoprolol, the combination application of amiodarone and metoprolol has the best effect of ending PSVT and reducing blood pressure.

关 键 词：室上性心动过速 普罗帕酮 胺碘酮 倍他乐克 联合用药 

分 类 号：R541.7[医药卫生—心血管疾病]