不同浓度香丹注射液对任意皮瓣成活的影响  

The effects of different concentrations of Xiangdan injection on skin flap survival

作　　者：陶思一[1] 马红丽[2] 胡高[2] 周占伟[3] 齐静[1] 

机构地区：[1]蚌埠医学院第二附属医院急诊科,安徽蚌埠233040 [2]蚌埠医学院第二附属医院整形外科,安徽蚌埠233040 [3]蚌埠医学院流行病与卫生统计学教研室,安徽蚌埠233030

出　　处：《蚌埠医学院学报》2012年第12期1415-1417,共3页Journal of Bengbu Medical College

基　　金：安徽省蚌埠市医疗卫生指导科技计划项目(2009-17)

摘　　要：目的:探讨不同浓度香丹注射液对任意皮瓣成活长度的影响。方法:将15只大白兔均分为A、B、C、D、E 5组,在兔背侧手术形成16 cm×2 cm的超长皮瓣后原位回植,术后A、B、C、D组分别按4 ml·kg-1·d-1静脉推注6%、12%、24%、48%香丹注射液,E组静脉推注生理盐水作对照,2周时观察记录各组皮瓣成活长度,以及在各皮瓣相同位置的组织细胞状况。结果:B、C组皮瓣成活长度明显大于A、D、E组(P<0.01),而E组成活长度最短;镜下观察,B、C组均见大量纤维细胞增生修复,组织坏死少,A组纤维细胞增生少,组织坏死较多,而D、E组纤维细胞增生最少,组织坏死最多。结论:应用12%～24%浓度的香丹注射液更有利于促进任意皮瓣成活。Objective：To invstigate the effects of different concentrations of the Xiangdan injection on the survival length of skin flap. Methods：Fifteen rabbits were randomly divided into 5 groups（group A,B,C,D and E）,which were made a 16 cm×2 cm skin flap at back of rabbit,then the skin flap was in situ transplanted.Group A,B,C and D were given Xiangdan injection of 4 ml·kg-1·d-1 with the concentration of 6%,12%,24%,and 48% respectively after operation,while group E was given normal saline as control.The skin flap survival status were recorded and the pathological changes were observed by HE stain in two weeks after operation. Results：The length of skin flat survival of group B and C were longer than that of group A,D and E（P0.01）,and that of group E was the shortest.More fibrous proliferation and little tissue necrosis were found in group B and C,little fibrous proliferation and more tissue necrosis in group A and little fibrous proliferation and most tissue necrosis in group D and E under microscope. Conclusions：The 12%-24% concentrations of Xiangdan injection can improve the random skin flap survival.

关 键 词：外科皮瓣 香丹注射液 成活 长度 浓度 

分 类 号：R622.1[医药卫生—整形外科]