血浆胱蛋白酶抑制剂C在评估肾小球滤过率中的应用  

Application of plasma cystatin C in assessing glomerular filtration rate

作　　者：邓蓉[1] 杨萍[1] 郑晶[1] 郑照军[1] 

机构地区：[1]蚌埠医学院第一附属医院检验科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2012年第12期1528-1529,1532,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨胱蛋白酶抑制剂C(cystatin C)在评估肾小球滤过率中的价值。方法:将109例患者按内生肌酐清除率(Ccr)水平分4组:肾功能正常组(Ccr≥80 ml/min)33例,肾功能不全代偿组(50 ml/min≤Ccr<80 ml/min)20例,肾功能失代偿组(20 ml/min≤Ccr<50 ml/min)27例,肾功能衰竭组(Ccr<20 ml/min)29例;另设正常对照组69名。分别检测观察对象血浆cystatin C、血肌酐(Scr)、尿素氮水平,计算其Ccr,并将结果进行统计学分析。结果:其他肾功能组cystatin C结果与健康对照组比较,差异均有统计学意义(P<0.01),并随着Ccr的下降而上升,且与Ccr和Scr均具有较好的相关关系(P<0.01)。结论:血浆cystatin C检测是判断肾小球滤过功能的敏感指标,其结果可替代内生Ccr。Objective：To explore the value of cystatin C in assessing glomerular filtration rate. Methods：One hundred and nine patients were devided into 4 groups according to the level of endogenous creatinine clearance rate（Ccr）,which included normal renal function group（Ccr≥80 ml/min,n=33）,renal insufficiency compensation group（50 ml/min≤Ccr80 ml/min,n=20）,renal insufficiency decompensation group（20 ml/min≤Ccr50 ml/min,n=27） and renal failure group（Ccr20 ml/min,n=29）.Sixty-nine healthy people were set as control group.The levels of cystatin C,Scr and urea nitrogen in blood plasma of all group were determined,which were statistically analyzed. Results：Compared with control group,there were significant differences in the cystatin C levels of other groups（P0.01）.The levels of Cystatin C increased along with the Ccr levels decline.There were good relevant relationships between Ccr and Scr（P0.01）. Conclusions：Blood plasma cystatin C is a sensitive indicator for evaluating the glomerular filtration function,which can replace the role of Ccr.

关 键 词：肾功能衰竭 胱蛋白酶抑制剂C 肾小球滤过率 内生肌酐清除率 

分 类 号：R692.5[医药卫生—泌尿科学]