甲氨基阿维菌素的致突变性、致畸性及亚慢性毒性的研究  

STUDIES ON THE MUTAGENICITY, TERATOGENICITY AND SUBCHRONIC TOXICITY OF METHYLAMINO ABAMECTIN

作　　者：邢彩虹[1] 戴宇飞[1] 常平[1] 张林林[1] 李桂兰[1] 尹松年[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,北京100050

出　　处：《癌变．畸变．突变》2000年第3期156-161,共6页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的与方法 :本文报道了甲氨基阿维菌素小鼠骨髓嗜多染红细胞微核试验 ,小鼠精子畸形试验 ,Ames试验 ,对大鼠的亚慢性毒性试验及致畸试验的研究结果。结果与结论 :其剂量在 6.3～ 2 5.2mg/kg的微核试验结果表明 ,各剂量组与阴性对照组的微核率比较 ,结果无显著意义 (P >0 0 5)。 1 0～ 50 0 μg/皿剂量组Ames试验及 1 5.8～ 63mg/kg .bw剂量组小鼠精子畸形试验结果均为阴性。致畸研究结果表明 ,该药对大鼠无明显母体毒作用和胚胎毒作用。亚慢性毒性试验中 ,高剂量组雌性大鼠 (9.2 6mg/kg .bw)尿素氮、雄性大鼠 (1 2 .6mg/kg .bw)尿素氮及白蛋白水平有一定程度的改变 ,雄、雌性大鼠肾脏脏器系数有显著的改变 (P <0 0 5)。雄性大鼠 (1 2 .6mg/kg .bw)体重明显降低 (P <0 0 5) ,比雌性大鼠影响略大。亚慢性毒性最大耐受剂量雌性大鼠为 1 .1 6mg/kg .bw ,雄性大鼠为 1 .57mg/kg .bw。Purpose and Methods: Mutagenicity, teratogenicity and subchronic toxicity in mice or rats induced by Methylamino Abamectin(MA) were studied. Results and Conclusion: In comparison with negative control, each dosage did not show significant differences in the rates of marrow cell micronuclei and spermatic deformity of mice (P>0.05); but revealed significant difference compared to positive control (P<0.05). MA(10 500μg/plate) didn't induce positive mutations of strains TA97,TA98,TA100 and TA102 with or without S9\-\{mix\} in Ames test. It suggested that MA has no obvious mutagenicity and embryotoxic or teratogenic effects in Wistar rats. At the highest dosage, BUN and Albumin at 12.6mg/kg.bw in females showed significant diffence (P<0.05), so did BUN at 9.26mg/kg.bw in males (P<0.05). Body weights were decreased in males and organ coefficient of kidney was increased in males ad females. The maximum no observed effect level of MA in subchromic toxicity was 1.16mg/kg.bw and 1.57mg/kg.bw in males and females, respectively.

关 键 词：甲基阿维菌素 致突变性 亚慢性毒性 致畸性 

分 类 号：R979.8[医药卫生—药品]