2012年春北京抽检的啮齿类实验动物健康状况的病理学调查和分析  

Pathological Investigation and Analysis of Health Status of Laboratory Rodents Sampling from Beijing in May 2012

作　　者：刘进[1] 姚皓[1] 王敏[1] 林竹[1] 王继宏[1] 彭云[1] 宋志琦[1] 康静静[1] 潘博[1] 王运盛[1] 杨利峰[1] 尹晓敏[1] 周向梅[1] 赵德明[1] 

机构地区：[1]中国农业大学动物医学院/国家动物海绵状脑病实验室,北京100193

出　　处：《实验动物科学》2012年第6期1-4,共4页Laboratory Animal Science

基　　金：国家科技支撑计划;十二五实验动物新品种的种群建立与质量标准化研究(No.2011BAI15B01)

摘　　要：2012年5月本实验室对北京16家实验动物单位的啮齿类实验动物的心、肝、脾、肺、肾、大肠和小肠进行组织病理学观察,通过石蜡切片HE染色、冰冻切片油红O染色、PAS染色等方法对啮齿类实验动物的健康状况进行鉴定。结果显示,绝大多数啮齿类实验动物为健康状态,部分非健康动物主要有肝脏脂肪变性、轻度肺脏病变、心脏颗粒变性和肾脏蛋白管型。这可能与饲养环境、饲料状况以及采样运输的应激有关,通过加强饲养管理可以使这种情况改善。Some apparatuses such as heart, liver, spleen, lung, kidney, large intestine and small intestine were drawn from laboratory rodents sampling from 16 units of Beijing in May 2012, and were prepared into serial paraffin sections stained with HE and the frozen sections stained with Oil Red O and PAS for microscopic analysis. The results showed that most of the laboratory rodents remained in good condition, and liver fatty degeneration, slight lung lesion, heart granular degeneration and protein cast of kidney were revealed in a few laboratory rodents. We have the impression that these lesions may be associated with feedstuff, feeding environment and transportation stress, and may be improved by strengthening the feeding management.

关 键 词：啮齿类实验动物 病理学诊断 脏器病变 

分 类 号：Q953.3[生物学—动物学]