国产单硝酸异山梨醇酯药理研究——(Ⅰ)国产单硝酸异山梨醇酯对正常大鼠血流动力学的影响  

EFFECTS OF NATIVE ISMN ON HEMODYNAMICS IN NORMAL RATS

作　　者：金其泉[1] 顾丽英[1] 陶亮[1] 祝晓光[1] 刘永宏 陈桂英[1] 

机构地区：[1]蚌埠医学院药理学教研室

出　　处：《蚌埠医学院学报》1991年第3期197-200,共4页Journal of Bengbu Medical College

摘　　要：国产ISMN对正常大鼠在早期均可使血压显著降低(P<0.01),但随即迅速恢复,在其他血流动力学指标方面,LVSP和LVEDP值均明显低于对照组(P<0.01),对±dp/dtmax与HR均无影响(P<0.05),但在25mg/kg剂量时,±dp/dtmax降低明显(P 0.01),实验结果表明,国产ISMN作为一种抗心绞痛新药,有进一步研究的价值。The blood pressure in the early stage decreased obviously with use of native isosorbide mononitrate ( ISMN ) . but recovered rapidly. As far as other hemodynamics were concerned, the values of LVSP and LVEDP were decreased ( P<0, 001 ), but no significant effects were observed on ±dp/dtmax and HR ( P>0. 05 ) . I n 25mg/kg of ISMN, ±dp/dt max were decreased ( P <0.01 ). The results showed that native ISMN could be a promising new type of antianginal drug, worthy of forther reseaching.

关 键 词：硝酸异山梨醇 单硝酸 药理学 

分 类 号：R965[医药卫生—药理学]