载当归羧甲基纤维素-海藻酸钠复合微球的制备和表征  

Preparation and Characterization of CMC-SA Composite Micropheres Loaded Angelica Sinensis Diels

作　　者：罗小兵[1] 刘俊[1] 董会宁[1] 周闲菊[1] 陈希明[1] 

机构地区：[1]重庆邮电大学应用物理研究所,重庆400065

出　　处：《材料导报》2013年第2期8-11,共4页Materials Reports

基　　金：重庆自然科学基金(CSTC;2010BB0405);国家重点基础研究发展计划(973计划)(2007CB936102);重庆邮电大学博士启动基金(A2012-32)

摘　　要：采用W/O乳液法,在不同条件下,用Ca2+交联和戊二醛交联制备了羧甲基纤维素(CMC)-海藻酸钠(SA)复合微球。SEM结果显示,当m(CMC)∶m(SA)=1∶5、温度为60℃时,球形较好。采用FT-IR分析了复合微球的化学结构。对复合微球的溶胀率、药物包封率进行表征,结果显示复合微球在磷酸缓冲液中的溶胀率达到700%,且溶胀速度快。该复合微球对当归(ASD)具有较好的缓释作用。The carboxymethyl cellulose （CMC）/ sodium alginate （SA） composite microspheres were prepared by a water-in-oil emulsion technique with Ca2＋ and glutaraldehyde（GA） as cross-linking agent in the various factors such as temperature, different CMC/SA weight ratio. Scanning electron microscopy（SEM） was used to characterize the formation of micropheres. The microspheres with optimal properties were prepared in a composition of rn（CMC）/ rn（SA） =1 ： 5 at 60 ℃. The structure of the composite micropheres was characterized by using Fourier transform infrared spectroscopy （FT-IR）. The swelling ratio of micropheres was about 700% in PBS （phosphate buffered saline）. And the swelling controlled-release systems were showed for the delivery of angelica sinensis diels（ASD） at controlled rates.

关 键 词：羧甲基纤维素 海藻酸钠 当归 复合微球 

分 类 号：TB34[一般工业技术—材料科学与工程] TB302.1