芬布芬插层Mg/Fe-NO_3-LDHs复合材料的组装及其缓释性能的研究  

Assembly and Release Behavior of Fenbufen-intercalated Mg/Fe-NO_3-LDHs Composite

作　　者：杜宝中[1] 张青[1] 彭振国[1] 杨国农[1] 

机构地区：[1]西安理工大学应用化学系,西安710048

出　　处：《材料导报》2013年第2期35-39,60,共6页Materials Reports

基　　金：西安市工业科技攻关项目(YF07058)

摘　　要：采用共沉淀法合成Mg/Fe-NO3-LDHs前体,通过正交试验考察了镁铁物质的量比、pH值、反应温度及时间对产物结构和物相的影响,确定了最佳合成条件(Mg、Fe物质的量比为3,pH值为9,反应温度为65℃,反应时间为4h)。再以共沉淀法组装芬布芬-LDHs,利用XRD、FT-IR、UV、TG-DTA对产物进行了结构表征,插层量19.6%。测试芬布芬-LDHs在模拟肠液、生理盐水及蒸馏水中的缓释性能,结果表明其在不同的缓释介质中均具有较好的缓释效果。释放过程符合准二级动力学方程,芬布芬在LDHs层间的扩散是释放控制步骤。Mg/Fe-NO3-LDHs was prepared with nitrate as the raw material by the method of co-precipitation under atmosphere of N2. The effect of magnesium iron molar ratio, pH, reaction temperature and reaction time on the structure and property of product were studied by orthogonal experiment which optimized the synthetic process. The products were analyzed by XRD, the optimum conditions for the Mg/Fe molar ratio is 3, pH is around 9, reaction temperature 65 ℃, 4 h for reaction time. Under optimum conditions, co-precipitation method was used to leading the guest of drug anions into LDHs layers to achieve fenbufen-LDHs intercalation. Using XRD, FT-IR, UV, TG-DTA to characterize the product, the capacity of fenbufen can reach to 19.6% by co-precipitation method. The controlled release properties of fenbufen-LDHs was investigated in simulated intestinal fluid, normal saIine and distilled water. The result shows that there were slow-release effect in different media. The release kinetics of fenbufen from the composite was investigated in buffer, and it was found that the release process may fit to the pseudo-second order release kinetics and the diffusion through the LDHs particle of fenbufen played an important role in controlling the drug release rate.

关 键 词：Mg Fe-NO3-LDHs 芬布芬 插层组装 缓释 

分 类 号：TQ324[化学工程—合成树脂塑料工业]