利奈唑胺与万古霉素对耐甲氧西林金黄色葡萄球菌抗生素后效应的研究  

Post-antibiotic effect of linezolid and vancomycin against methicillin-resistant Staphyloccus aureus

作　　者：梁蓓蓓[1] 王瑾[1] 白楠[1] 周家军[1] 裴广胜[1] 王睿[1] 

机构地区：[1]中国人民解放军总医院药物临床研究中心,北京100853

出　　处：《中国临床药理学杂志》2013年第1期31-33,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的研究利奈唑胺和万古霉素对耐甲氧西林金黄色葡萄球菌(MR-SA)的体外抗生素后效应(PAE)。方法用平板菌落计数法测定不同接触浓度、不同接触时间的利奈唑胺和万古霉素对MRSA的PAE;用扫描电镜观察两药PAE期间MRSA形态学的变化。结果利奈唑胺和万古霉素对MR-SA均能产生中度PAE,且随着接触时间的延长、接触浓度的增加,PAE延长。与空白对照组比较,在体外PAE期间没有观察到两药MRSA形态有显著的变化。结论利奈唑胺和万古霉素在体外对MRSA均能产生中度PAE,两药在体外PAE期间MRSA形态无明显的变化。Objective To investigate the post- antibiotic effect （PAE） of linezolid and vancomycin against methicillin - resistant Staphyloccus aureus （MRSA）. Methods PAE of linezolid and vancomycin against MRSA was determined by plate colony counting at different concentrations（1 × MIC,2 × MIC,4 ×MIC,8 × MIC） and different time points （ 1,2,3 h）. The morphological changes of MRSA during the PAE period were observed by scanning electron microscopy. Results All strains were susceptible to linezolid and vancomycin. The PAE was greater at higher concentration and longer exposure time. There was no morphological change of MRSA during the PAE. Conclusion It was demonstrated that linezolid and vacomycin had a moderate in vitro PAE against MRSA. There was no morphological change of MRSA during the PAE.

关 键 词：利奈唑胺 万古霉素 抗生素后效应 

分 类 号：R978.19[医药卫生—药品] R969.1[医药卫生—药学]