职业性慢性镉中毒早期肾功能损害的分析  

Analysis of Early Renal Damage in Occupational Chronic Cadmium Poisoning

作　　者：余燕湘 李颖 肖雄斌 李莉 张晓华 

机构地区：[1]湖南省职业病防治院,湖南长沙410007

出　　处：《实用预防医学》2013年第1期66-67,共2页Practical Preventive Medicine

基　　金：湖南省卫生厅一般项目(C2012-028);湖南省科技厅项目(2011WK3056)

摘　　要：目的探讨职业性慢性镉中毒肾早期损害指标,为及时发现镉中毒提供科学依据。方法回顾分析湖南省职业病防治院收治的59名职业性慢性轻度镉中毒患者的临床资料,分别对尿镉、工龄与尿视黄醇结合蛋白、尿β2微球蛋白之间关联进行综合分析。结果尿镉与尿视黄醇结合蛋白之间无相关性(P>0.05),工龄与肾早期损害指标之间无相关性(P>0.05),但尿镉与尿β2微球蛋白存在剂量效应曲线(P<0.05),镉中毒患者,尿视黄醇结合蛋白的敏感性要高于尿β2微球蛋白(P<0.05)。结论工龄长短与肾早期损害指标之间无直线相关关系,尿β2微球蛋白水平随着尿镉浓度的增高而增高。Objective To explore the indexes of early renal damage in occupational chronic cadmium poisoning, and to provide a scientific basis for timely detecting cadmium poisoning. Methods We retrospectively analyzed the clinical data about 59 inpatients with mild occupational chronic cadmium poisoning, and the correlation between urinary cadmium, cadmium exposure duration and urinary 132 microglobulin, urinary retinol binding protein was synthetically analyzed. Results No association was found between urinary cadmium and urinary retinol binding protein （P 〉0.05） as wall as between cadmium exposure dura- tion and early renal damage （P 〉 0.05）, but there was a doseresponse curve between urinary cadmium and urinary β2 micro- globulin （P 〈 0.05）. Among the patients with cadmium poisoning, the sensitivity of urinary retinol- binding protein was higher than that of urinary β2 microglobulin （P〈 0.05）. Conclusions There was no linear correlation between service length and the indicators of early renal damage. The level of urinary β2 microglobulin was increased with the increase of urinary cadmium concentrations.

关 键 词：镉中毒 肾功能 分析 

分 类 号：R135[医药卫生—劳动卫生]