胶质瘤中MCP-1表达、TAMs募集及其相关性研究  

Relationship between the expression of monocyte chemoattractant protein-1 and the recruitment of tumor-associated macrophage in glioma

作　　者：陆斌[1] 丁鹏[1] 王进昆[1] 杨智勇[1] 王伟民[1] 王宏宇[1] 

机构地区：[1]昆明医学院第一附属医院神经外科,云南昆明650032

出　　处：《中华神经外科疾病研究杂志》2012年第6期508-511,共4页Chinese Journal of Neurosurgical Disease Research

基　　金：云南省自然科学基金资助项目(2010CD157)

摘　　要：目的探讨胶质瘤中单核细胞趋化蛋白-1(MCP-1)表达与肿瘤相关巨噬细胞(TAMs)的相互关系及其临床病理意义。方法采用免疫组化方法(SABC)检测不同级别胶质瘤中的MCP-1、CD68的平均阳性表达率。结果不同级别胶质瘤中,MCP-1、CD68阳性表达率有显著性差异(P<0.05),并且MCP-1、CD68随着胶质瘤级别的增高,阳性表达率也不断增加。结论 MCP-1、TAMs在人胶质瘤发生、发展及相关生物学行为中起着重要的作用,且二者之间具有相互协同作用。Objective To investigate the relationship between the expressions of monocyte chernoattractant protein-1 （MCP-1） and tumor-associated macrophages （TAMs） in glioma and its clinicopathological significance. Methods The average positive rates of MCP-1 and CD68 in gliomas with different malignancy were detected by immunohistochemical SP. Results The positive expression rates of MCP-1 and CD68 in gliomas with different malignaney were significant different （P 〈0.05）. The positive rates of MCP-1 and CD68 were increased with the malignancy of glioma. Conclusion MCP-1 and TA Ms may play an important role in the progression and the biological behaviors of human gliomas and there is a synergism between them.

关 键 词：MCP-1 CD68 胶质瘤 血管生成 免疫组化 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]