Mechanism of anti-arterial thrombosis of Dahuangzhecong Fang screened by Ti-Al intermetallic compound porous material  

钛铝金属间化合物多孔材料筛选大黄蛰虫方抗动脉血栓形成机理(英文)

作　　者：万玲[1] 王战义 魏星[1] 李佶阳[1] 钟广伟[1] 段晓鹏[3] 贺福元[3] 江垚[4] 王东生[1] 

机构地区：[1]中南大学湘雅医院,长沙410008 [2]河南禹州市中医院,禹州461670 [3]湖南中医药大学,长沙410208 [4]中南大学粉末冶金学院,长沙410083

出　　处：《Transactions of Nonferrous Metals Society of China》2012年第12期3156-3160,共5页中国有色金属学报（英文版）

基　　金：Project (2010FA32370) supported by The Ministry of Science and Technology of China;Project (2008WK3002) supported by Hunan Provincial Science and Technology Department;Project (20060390891) supported by the Postdoctoral Science Foundation of China

摘　　要：The mechanism of antithrombotic of Dahuangzhechong Fang separated and purified by Ti-Al intermetallic compound porous material (TAICPM) was researched. Dahuangzhechong Fang, which was isolated and screened by TAICPM, was used to oral rats. At the end of study, their blood and thrombus were collected. The results show that TAICPM with the pore size of 1-5 μm can screen Dahuangzhechong Fang well. Dahuangzhechong Fang can increase 6-keto-PGF1α, lower content of TXD2 and platelet. Dahuangzhechong Fang has good effect to resist arterial thrombosis.探讨经过钛铝金属间化合物多孔材料分离筛选的大黄蛰虫方抗血栓形成机理。将通过钛铝金属间化合物多孔材料分离筛选的大黄蛰虫方干预大鼠,收集血液、血栓。结果表明,钛铝金属间化合物多孔材料能有效分离筛选大黄蛰虫方,以孔径为15μm的效果最优。大黄蜇虫方能升高6-keto-PGF1α,降低TXD2,降低血小板含量,有良好的抗动脉血栓形成作用。多孔材料处理过的药物具有良好的抗血栓形成作用。

关 键 词：Ti-Al intermetallic compound porous materials Dahuangzhecong Fang arterial thrombosis isolated Chinese medicine 

分 类 号：R285[医药卫生—中药学]