大黄有效期的研究  

Research on the Period of Validity of Rhubarb

作　　者：杨磊[1] 朱青[2] 张志国[1] 曹臣[1] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南省肿瘤医院,湖南长沙410013

出　　处：《安徽农业科学》2012年第36期17534-17535,17537,共3页Journal of Anhui Agricultural Sciences

基　　金：湖南省自然科学基金项目(编号:10JJ5018)

摘　　要：[目的]对中药材大黄的有效期进行研究。[方法]选用易氧化变色的大黄,通过经典恒温试验,采用HPLC测定大黄酸、大黄素、大黄素甲醚、芦荟大黄素的含量,并研究该药有效成分含量的变化规律。[结果]经典恒温法测定的大黄酸、大黄素、大黄素甲醚、芦荟大黄素含量变化符合一级反应规律。在20℃的储藏条件下,大黄有效成分的含量变化速度常数为K=1.585×10-5,该批大黄有效期为687 d。[结论]用经典恒温法预测中药材大黄有效期,结论可靠。[Objective] To study the period of validity of traditional Chinese medicine rhubarb.[Method] Easily oxidized rhubarb was selected.Based on classic constant temperature experiment,contents of rhein,archen,physcion and aloe-emodin were detected by HPLC.The change law of the effective components contents in rhubarb was deduced.[Result] Changes of rhein,archen,physcion and aloe-emodin contents were followed the first-order reaction law.Under the storage condition of 20 ℃,the change rate constant of rhubarb was K=1.585×10-5;and the period of validity of this batch of rhubarb was 687 d.[Conclusion] It was feasible to forecast the validity period of rhubarb by classic constant temperature experiment,and the result was reliable.

关 键 词：大黄(RADIX ET RHIZOMA RHEI) 经典恒温试验 含量测定 有效期 

分 类 号：S567[农业科学—中草药栽培]