肾素血管紧张素系统阻滞剂对IgA肾病转化生长因子1的抑制效应  

Inhibitory effect of RAS blockers on TGF-1 in IgA nephropathy

作　　者：周莹[1] 吕吟秋[1] 黄朝兴[1] 

机构地区：[1]温州医学院附属第一医院,浙江省温州325000

出　　处：《现代实用医学》2012年第12期1327-1329,共3页Modern Practical Medicine

基　　金：浙江省温州市科技计划项目(Y2006A029)

摘　　要：目的探讨肾素血管紧张素系统(RAS)阻滞剂对IgA肾病(IgAN)患者血和尿转化生长因子1(TGF-1)的影响及其意义。方法比较12例长期服用小剂量血管紧张素转化酶抑制剂(ACEI)或血管紧张素Ⅱ受体阻滞剂(ARB)的IgAN患者和11例均未服用上述药物的患者治疗前后血和尿的TGF-1及临床参数的变化。结果 12例IgAN患者在长期服用RAS阻滞剂后其尿TGF-1和8 h尿蛋白均较治疗前降低,未经上述药物治疗的11例IgAN患者的尿TGF-1及8h尿蛋白均较治疗前明显上升。结论使用小剂量的RAS阻滞剂可明显降低IgAN尿TGF-1的水平,但不能将其降至正常范围,且不能完全阻断疾病的进展。Objective To investigate the influencing of renin-angiotensin system（RAS） on changes of blood and urine transforming growth factor-1（TGF-β1） in IgA nephropathy patients and its significance.Methods Twentythree patients with IgA nephropathy patients were enrolled in this study;among which,12 cases were with long-term use small doses of angiotensin 1-converting enzyme inhibitors（ACEI） or Ⅱ angiotensin receptor blockers（ARB）,and the other 11 cases did not take the drugs.Enzyme-linked immunosorbent assay（ELISA） to measure blood and urine TGF-β1 before and after treatment and clinical parameters were examined.Results tUrine TGF-β1 and 8 h urine protein level were significantly decreased at the end of the observation period among the 12 patients who took the drugs;and urine TGF-1 and 8h urine protein level were increased dramatically in 11 cases who did not take drugs.Conclusions Small doses of RAS blockers can obviously reduce IgA nephropathy urine TGF-β1 level,but can＇t bring it down to normal range,and can＇t completely blocked the progress of the disease.

关 键 词：肾小球肾炎 IGA 转化生长因子1 肾素-血管紧张素系统 

分 类 号：R692[医药卫生—泌尿科学]