早孕妇女血清IGF-Ⅰ、IGFBP-3检测临床意义分析  

Significance analysis of maternal serum IGF-Ⅰ,IGFBP-3 content

作　　者：陈载融[1,2] 李菡[1,2] 徐佩[1,2] 

机构地区：[1]南京大学医学院附属医院 [2]南京鼓楼医院,江苏南京210008

出　　处：《国际检验医学杂志》2012年第19期2323-2324,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨早孕妇女血清胰岛素样生长因子Ⅰ(IGF-Ⅰ)、胰岛素样生长因子结合蛋白3(IGFBP-3)含量检测的临床意义。方法选择体外受精与胚胎移植术(IVT-ET)患者,以术后第14天人绒毛膜促性腺激素β亚基(β-HCG)阴性者为试验组A(30例),β-HCG>650.00mIU/mL为试验组B(30例)。以健康孕6周妇女为试验组C(30例)。测定各组IGF-Ⅰ、IGFBP-3。结果试验组B血清IGF-Ⅰ、IGFBP-3含量低于试验组A(P<0.05);试验组CIGF-Ⅰ高于试验组A及试验组B(P<0.05);试验组CIGFBP-3与试验组A无统计学差异(P>0.05),但高于试验组B(P<0.05);IGF-Ⅰ、IGFBP-3呈正相关(r=0.7667)。结论 IVT-ET术后14d,孕妇血清IGF-Ⅰ、IGFBP-3含量均偏低;随孕期延长、胎盘形成,IGF-Ⅰ、IGFBP-3含量迅速增加。孕妇血清IGF-Ⅰ、IGFBP-3可用于预测胚胎发育、胎儿生长状况。Objective To explore the clinical significance of maternal serum insulin-like growth factor Ⅰ（IGF-Ⅰ） and insulin-like growth factor binding protein 3（IGFBP-3） content.Methods In vitro fertilization and embryo transfer（IVT-ET） patients were selected and detected for β-human chorionic gonadotropin（β-HCG） at the 14th day post-operation.Patients negative with β-HCG was enrolled into group A for 30 cases,those with β-HCG650.00 mIU/mL into group B for 30 cases.Normal 6 weeks pregnant women were enrolled into group C for 30 cases.Serum IGF-Ⅰ and IGFBP-3 were detected.Results Serum content of IGF-Ⅰ and IGFBP-3 in group B were significantly lower than those in group A（P0.05）.IGF-Ⅰ level in group C was higher than that in group A and B（P0.05）.Group C and A were with no difference for IGFBP-3,but IGFBP-3 content was significantly higher in group B（P0.05）.IGF-Ⅰ and IGFBP-3 were related（r=0.766 7）.Conclusion On the 14th day post IVT-ET,maternal serum IGF-I and IGFBP-3 content might be low,but could increase with the prolonged pregnant and placenta formation.Maternal serum IGF-Ⅰ and IGFBP-3 could be used to predict the development of embryos and fetal growth status.

关 键 词：胰岛素样生长因子Ⅰ 胰岛素样生长因子结合蛋白3 胚胎发育 

分 类 号：R446.6[医药卫生—诊断学]